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dc.contributor.authorZee, R. Y. L.
dc.contributor.authorRidker, P. M.
dc.contributor.authorStampfer, Meir
dc.contributor.authorHennekens, C. H.
dc.contributor.authorLindpaintner, K.
dc.date.accessioned2019-09-06T15:39:05Z
dc.date.issued1999
dc.identifier.citationZee, Robert Y.L., Paul M. Ridker, Meir J. Stampfer, Charles H. Hennekens, and Klaus Lindpaintner. 1999. “Prospective Evaluation of the Angiotensin-Converting Enzyme Insertion/Deletion Polymorphism and the Risk of Stroke.” Circulation 99 (3): 340–43. https://doi.org/10.1161/01.cir.99.3.340.
dc.identifier.issn0009-7322
dc.identifier.issn0069-4193
dc.identifier.issn1524-4539
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:41292984*
dc.description.abstractBackground-The D/I polymorphism of the ACE gene has been studied in relation to a variety of cardiovascular disorders, including stroke. A number of small studies have been conducted, with inconsistent results. We investigated the association between ACE genotype and the incidence of stroke in a large, prospective, matched case-control sample from the Physicians' Health Study.Methods and Results-In the Physicians' Health Study, 348 subjects who had been apparently healthy at enrollment suffered a stroke during 12 years of follow-up, as determined from medical records and autopsy. A total of 348 cases were matched by age, time of randomization, and smoking habit to an equal number of controls (who had remained free of stroke). The D/I polymorphism was determined by polymerase chain reaction, Data were analyzed for the entire nested case-control sample, and also among a subgroup without a history of hypertension or diabetes mellitus, considered to be at low conventional risk (207 cases and 280 controls). All observed genotype frequencies were in Hardy-Weinberg equilibrium. The relative risk associated with the D allele was 1.11 (95% CI, 0.90 to 1.37; P=0.35), assuming an additive model in the matched analysis. Additional analyses assuming dominant or recessive effects of the D allele, as well as the analysis after stratification for low-risk status, showed no material as a statistically significant association.Conclusions-The results of this large, prospective study indicate that the ACE D/I gene polymorphism is not associated with subsequent risk of stroke.
dc.language.isoen_US
dc.publisherAmerican Heart Association
dash.licenseMETA_ONLY
dc.titleProspective Evaluation of the Angiotensin-Converting Enzyme Insertion/Deletion Polymorphism and the Risk of Stroke
dc.typeJournal Article
dc.description.versionVersion of Record
dc.relation.journalCirculation
dash.depositing.authorStampfer, Meir
dc.date.available2019-09-06T15:39:05Z
dash.workflow.comments1Science Serial ID 20849
dc.identifier.doi10.1161/01.CIR.99.3.340
dash.source.volume99;3
dash.source.page340-343
dash.contributor.affiliatedStampfer, Meir


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