Photoactivatable Drug-Caged Fluorophore Conjugate Allows Direct Quantification of Intracellular Drug Transport
Agasti, Sarit S.
Laughney, Ashley M.
Kohler, Rainer H.
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CitationAgasti, Sarit S., Ashley M. Laughney, Rainer H. Kohler, and Ralph Weissleder. 2013. “A Photoactivatable Drug–caged Fluorophore Conjugate Allows Direct Quantification of Intracellular Drug Transport.” Chemical Communications 49 (94): 11050. https://doi.org/10.1039/c3cc46089d.
AbstractWe report here a method that utilizes a photoactivatable drug-caged fluorophore conjugate to quantify intracellular drug trafficking processes at single cell resolution. Photoactivation is performed in labeled cellular compartments to visualize intracellular drug exchange under physiological conditions, without the need for washing, facilitating its translation into in vivo cancer models.
Citable link to this pagehttp://nrs.harvard.edu/urn-3:HUL.InstRepos:41384184
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