Innate Response Activator B Cells Protect Against Microbial Sepsis
Rauch, Philipp J.
Robbins, Clinton S.
Weber, Georg F.
Waring, Michael T.
Chicoine, Adam T.
Pittet, Mikael J.
Swirski, Filip K.
MetadataShow full item record
CitationRauch, P. J., A. Chudnovskiy, C. S. Robbins, G. F. Weber, M. Etzrodt, I. Hilgendorf, E. Tiglao, et al. 2012. “Innate Response Activator B Cells Protect Against Microbial Sepsis.” Science 335 (6068): 597–601. https://doi.org/10.1126/science.1215173.
AbstractRecognition and clearance of a bacterial infection are fundamental properties of innate immunity. Here, we describe an effector B cell population that protects against microbial sepsis. Innate response activator (IRA) B cells are phenotypically and functionally distinct, develop and diverge from B1a B cells, depend on pattern-recognition receptors, and produce granulocyte-macrophage colony-stimulating factor. Specific deletion of IRA B cell activity impairs bacterial clearance, elicits a cytokine storm, and precipitates septic shock. These observations enrich our understanding of innate immunity, position IRA B cells as gatekeepers of bacterial infection, and identify new treatment avenues for infectious diseases.
Citable link to this pagehttp://nrs.harvard.edu/urn-3:HUL.InstRepos:41384252
- HMS Scholarly Articles 
Contact administrator regarding this item (to report mistakes or request changes)