Innate Response Activator B Cells Protect Against Microbial Sepsis

 
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Rauch, Philipp J.
Chudnovskiy, Aleksey
Robbins, Clinton S.
Weber, Georg F.
Etzrodt, Martin
Hilgendorf, Ingo
Tiglao, Elizabeth
Figueiredo, Jose-Luiz
Iwamoto, Yoshiko
Theurl, Igor
Gorbatov, Rostic
Waring, Michael T.
Chicoine, Adam T.
Mouded, Majd
Pittet, Mikael J.
Nahrendorf, Matthias
Weissleder, Ralph
Swirski, Filip K.
Published Version
https://doi.org/10.1126/science.1215173
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Rauch, P. J., A. Chudnovskiy, C. S. Robbins, G. F. Weber, M. Etzrodt, I. Hilgendorf, E. Tiglao, et al. 2012. “Innate Response Activator B Cells Protect Against Microbial Sepsis.” Science 335 (6068): 597–601. https://doi.org/10.1126/science.1215173.
Abstract
Recognition and clearance of a bacterial infection are fundamental properties of innate immunity. Here, we describe an effector B cell population that protects against microbial sepsis. Innate response activator (IRA) B cells are phenotypically and functionally distinct, develop and diverge from B1a B cells, depend on pattern-recognition receptors, and produce granulocyte-macrophage colony-stimulating factor. Specific deletion of IRA B cell activity impairs bacterial clearance, elicits a cytokine storm, and precipitates septic shock. These observations enrich our understanding of innate immunity, position IRA B cells as gatekeepers of bacterial infection, and identify new treatment avenues for infectious diseases.
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http://nrs.harvard.edu/urn-3:HUL.InstRepos:41384252

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