dc.contributor.author | Robbins, Clinton S. | |
dc.contributor.author | Chudnovskiy, Aleksey | |
dc.contributor.author | Rauch, Philipp J. | |
dc.contributor.author | Figueiredo, Jose-Luiz | |
dc.contributor.author | Iwamoto, Yoshiko | |
dc.contributor.author | Gorbatov, Rostic | |
dc.contributor.author | Etzrodt, Martin | |
dc.contributor.author | Weber, Georg F. | |
dc.contributor.author | Ueno, Takuya | |
dc.contributor.author | Rooijen, Nico van | |
dc.contributor.author | Mulligan-Kehoe, Mary Jo | |
dc.contributor.author | Libby, Peter | |
dc.contributor.author | Nahrendorf, Matthias | |
dc.contributor.author | Pittet, Mikael J. | |
dc.contributor.author | Weissleder, Ralph | |
dc.contributor.author | Swirski, Filip K. | |
dc.date.accessioned | 2019-09-21T03:36:04Z | |
dc.date.issued | 2012 | |
dc.identifier.citation | Robbins, Clinton S., Aleksey Chudnovskiy, Philipp J. Rauch, Jose-Luiz Figueiredo, Yoshiko Iwamoto, Rostic Gorbatov, Martin Etzrodt, et al. 2012. “Extramedullary Hematopoiesis Generates Ly-6C High Monocytes That Infiltrate Atherosclerotic Lesions.” Circulation 125 (2): 364–74. https://doi.org/10.1161/circulationaha.111.061986. | |
dc.identifier.issn | 0009-7322 | |
dc.identifier.issn | 0069-4193 | |
dc.identifier.issn | 1524-4539 | |
dc.identifier.uri | http://nrs.harvard.edu/urn-3:HUL.InstRepos:41384259 | * |
dc.description.abstract | Background-Atherosclerotic lesions are believed to grow via the recruitment of bone marrow-derived monocytes. Among the known murine monocyte subsets, Ly-6C(high) monocytes are inflammatory, accumulate in lesions preferentially, and differentiate. Here, we hypothesized that the bone marrow outsources the production of Ly-6C(high) monocytes during atherosclerosis. Methods: and Results-Using murine models of atherosclerosis and fate-mapping approaches, we show that hematopoietic stem and progenitor cells progressively relocate from the bone marrow to the splenic red pulp, where they encounter granulocyte macrophage colony-stimulating factor and interleukin-3, clonally expand, and differentiate to Ly-6C(high) monocytes. Monocytes born in such extramedullary niches intravasate, circulate, and accumulate abundantly in atheromata. On lesional infiltration, Ly-6C(high) monocytes secrete inflammatory cytokines, reactive oxygen species, and proteases. Eventually, they ingest lipids and become foam cells. Conclusions: -Our findings indicate that extramedullary sites supplement the hematopoietic function of the bone marrow by producing circulating inflammatory cells that infiltrate atherosclerotic lesions. (Circulation. 2012; 125: 364-374.) | |
dc.language.iso | en_US | |
dc.publisher | American Heart Association | |
dash.license | LAA | |
dc.title | Extramedullary Hematopoiesis Generates Ly-6Chigh Monocytes that Infiltrate Atherosclerotic Lesions | |
dc.type | Journal Article | |
dc.description.version | Accepted Manuscript | |
dc.relation.journal | Circulation | |
dash.depositing.author | Weissleder, Ralph::ea07ce19f187d4fab47c56ee97fa5c5a::600 | |
dc.date.available | 2019-09-21T03:36:04Z | |
dash.workflow.comments | 1Science Serial ID 26637 | |
dc.identifier.doi | 10.1161/CIRCULATIONAHA.111.061986 | |
dash.source.volume | 125;2 | |
dash.source.page | 364 | |