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dc.contributor.authorWurdinger, Thomas
dc.contributor.authorBadr, Christian
dc.contributor.authorPike, Lisa
dc.contributor.authorKleine, Ruben de
dc.contributor.authorWeissleder, Ralph
dc.contributor.authorBreakefield, Xandra O.
dc.contributor.authorTannous, Bakhos A.
dc.date.accessioned2019-09-21T03:36:42Z
dc.date.issued2008
dc.identifier.citationWurdinger, Thomas, Christian Badr, Lisa Pike, Ruben de Kleine, Ralph Weissleder, Xandra O Breakefield, and Bakhos A Tannous. 2008. “A Secreted Luciferase for Ex Vivo Monitoring of in Vivo Processes.” Nature Methods 5 (2): 171–73. https://doi.org/10.1038/nmeth.1177.
dc.identifier.issn1548-7091
dc.identifier.issn1548-7105
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:41384309*
dc.description.abstractLuciferases are widely used to monitor biological processes. Here we describe the naturally secreted Gaussia princeps luciferase (Gluc) as a highly sensitive reporter for quantitative assessment of cells in vivo by measuring its concentration in blood. The Gluc blood assay complements in vivo bioluminescence imaging, which has the ability to localize the signal and provides a multifaceted assessment of cell viability, proliferation and location in experimental disease and therapy models.
dc.language.isoen_US
dc.publisherNature Research
dash.licenseLAA
dc.titleA secreted luciferase for ex-vivo monitoring of in vivo processes
dc.typeJournal Article
dc.description.versionAccepted Manuscript
dc.relation.journalNature Methods
dash.depositing.authorWeissleder, Ralph::ea07ce19f187d4fab47c56ee97fa5c5a::600
dc.date.available2019-09-21T03:36:42Z
dash.workflow.comments1Science Serial ID 71293
dc.identifier.doi10.1038/nmeth.1177
dash.source.volume5;2
dash.source.page171


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