Interorgan Communication Pathways in Physiology: Focus on Drosophila
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Droujinine, Ilia
Perrimon, Norbert
Published Version
https://doi.org/10.1146/annurev-genet-121415-122024Metadata
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Droujinine, Ilia A., and Norbert Perrimon. 2016. “Interorgan Communication Pathways in Physiology: Focus onDrosophila.” Annual Review of Genetics 50 (1): 539–70. https://doi.org/10.1146/annurev-genet-121415-122024.Abstract
Studies in mammals and Drosophila have demonstrated the existence and significance of secreted factors involved in communication between distal organs. In this review, primarily focusing on Drosophila, we examine the known interorgan communication factors and their functions, physiological inducers, and integration in regulating physiology. Moreover, we describe how organ-sensing screens in Drosophila can systematically identify novel conserved interorgan communication factors. Finally, we discuss how interorgan communication enabled and evolved as a result of specialization of organs. Together, we anticipate that future studies will establish a model for metazoan interorgan communication network (ICN) and how it is deregulated in disease.Terms of Use
This article is made available under the terms and conditions applicable to Open Access Policy Articles, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#OAPCitable link to this page
http://nrs.harvard.edu/urn-3:HUL.InstRepos:41384495
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