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dc.contributor.authorDroujinine, Ilia
dc.contributor.authorPerrimon, Norbert
dc.date.accessioned2019-09-21T09:03:22Z
dc.date.issued2016
dc.identifier.citationDroujinine, Ilia A., and Norbert Perrimon. 2016. “Interorgan Communication Pathways in Physiology: Focus onDrosophila.” Annual Review of Genetics 50 (1): 539–70. https://doi.org/10.1146/annurev-genet-121415-122024.
dc.identifier.issn0066-4197
dc.identifier.issn1545-2948
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:41384495*
dc.description.abstractStudies in mammals and Drosophila have demonstrated the existence and significance of secreted factors involved in communication between distal organs. In this review, primarily focusing on Drosophila, we examine the known interorgan communication factors and their functions, physiological inducers, and integration in regulating physiology. Moreover, we describe how organ-sensing screens in Drosophila can systematically identify novel conserved interorgan communication factors. Finally, we discuss how interorgan communication enabled and evolved as a result of specialization of organs. Together, we anticipate that future studies will establish a model for metazoan interorgan communication network (ICN) and how it is deregulated in disease.
dc.language.isoen_US
dc.publisherAnnual Reviews
dash.licenseOAP
dc.titleInterorgan Communication Pathways in Physiology: Focus on Drosophila
dc.typeJournal Article
dc.description.versionAccepted Manuscript
dc.relation.journalAnnual Review of Genetics
dash.depositing.authorPerrimon, Norbert::4e34fce71a186b488b1846b199007bfb::600
dc.date.available2019-09-21T09:03:22Z
dash.workflow.comments1Science Serial ID 6776
dc.identifier.doi10.1146/annurev-genet-121415-122024
dash.source.volume50
dash.source.page539


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