A Genome-Wide Gene Function Prediction Resource for Drosophila melanogaster
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Author
Yan, Han
Venkatesan, Kavitha
Beaver, John E.
Klitgord, Niels
Yildirim, Muhammed A.
Hao, Tong
Hill, David E.
Cusick, Michael E.
Perrimon, Norbert
Roth, Frederick P.
Vidal, Marc
Provart, Nicholas James
Published Version
https://doi.org/10.1371/journal.pone.0012139Metadata
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Yan, Han, Kavitha Venkatesan, John E. Beaver, Niels Klitgord, Muhammed A. Yildirim, Tong Hao, David E. Hill, et al. 2010. “A Genome-Wide Gene Function Prediction Resource for Drosophila Melanogaster.” Edited by Nicholas James Provart. PLoS ONE 5 (8): e12139. https://doi.org/10.1371/journal.pone.0012139.Abstract
Predicting gene functions by integrating large-scale biological data remains a challenge for systems biology. Here we present a resource for Drosophila melanogaster gene function predictions. We trained function-specific classifiers to optimize the influence of different biological datasets for each functional category. Our model predicted GO terms and KEGG pathway memberships for Drosophila melanogaster genes with high accuracy, as affirmed by cross-validation, supporting literature evidence, and large-scale RNAi screens. The resulting resource of prioritized associations between Drosophila genes and their potential functions offers a guide for experimental investigations.Terms of Use
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http://nrs.harvard.edu/urn-3:HUL.InstRepos:41384504
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