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dc.contributor.authorZirin, Jonathan
dc.contributor.authorPerrimon, Norbert
dc.date.accessioned2019-09-21T09:03:38Z
dc.date.issued2010
dc.identifier.citationZirin, Jonathan, and Norbert Perrimon. 2010. “Drosophila as a Model System to Study Autophagy.” Seminars in Immunopathology 32 (4): 363–72. https://doi.org/10.1007/s00281-010-0223-y.
dc.identifier.issn1863-2297
dc.identifier.issn1863-2300
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:41384510*
dc.description.abstractOriginally identified as a response to starvation in yeast, autophagy is now understood to fulfill a variety of roles in higher eukaryotes, from the maintenance of cellular homeostasis to the cellular response to stress, starvation, and infection. Although genetics and biochemical studies in yeast have identified many components involved in autophagy, the findings that some of the essential components of the yeast pathway are missing in higher organisms underscore the need to study autophagy in more complex systems. This review focuses on the use of the fruitfly, Drosophila melanogaster as a model system for analysis of autophagy. Drosophila is an organism well-suited for genetic analysis and represents an intermediate between yeast and mammals with respect to conservation of the autophagy machinery. Furthermore, the complex biology and physiology of Drosophila presents an opportunity to model human diseases in a tissue specific and analogous context.
dc.language.isoen_US
dc.publisherSpringer Verlag
dash.licenseLAA
dc.titleDrosophila as a model system to study autophagy
dc.typeJournal Article
dc.description.versionAccepted Manuscript
dc.relation.journalSeminars in Immunopathology
dash.depositing.authorPerrimon, Norbert::4e34fce71a186b488b1846b199007bfb::600
dc.date.available2019-09-21T09:03:38Z
dash.workflow.comments1Science Serial ID 92586
dc.identifier.doi10.1007/s00281-010-0223-y
dash.source.volume32;4
dash.source.page363


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