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dc.contributor.authorFriedman, Adam
dc.contributor.authorPerrimon, Norbert
dc.date.accessioned2019-09-21T09:03:43Z
dc.date.issued2004
dc.identifier.citationFriedman, Adam, and Norbert Perrimon. 2004. “Genome-Wide High-Throughput Screens in Functional Genomics.” Current Opinion in Genetics & Development 14 (5): 470–76. https://doi.org/10.1016/j.gde.2004.07.010.
dc.identifier.issn0959-437X
dc.identifier.issn1879-0380
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:41384515*
dc.description.abstractThe availability of complete genome sequences from many organisms has yielded the ability to perform high-throughput, genome-wide screens of gene function. Within the past year, rapid advances have been made towards this goal in many major model systems, including yeast, worms, flies, and mammals. Yeast genome-wide screens have taken advantage of libraries of deletion strains, but RNA-interference has been used in other organisms to knockdown gene function. Examples of recent large-scale functional genetic screens include drug-target identification in yeast, regulators of fat accumulation in worms, growth and viability in flies, and proteasome-mediated degradation in mammalian cells. Within the next five years, such screens are likely to lead to annotation of function of most genes across multiple organisms. Integration of such data with other genomic approaches will extend our understanding of cellular networks.
dc.language.isoen_US
dc.publisherElsevier
dash.licenseMETA_ONLY
dc.titleGenome-wide high-throughput screens in functional genomics
dc.typeJournal Article
dc.description.versionVersion of Record
dc.relation.journalCurrent Opinion in Genetics & Development
dash.depositing.authorPerrimon, Norbert::4e34fce71a186b488b1846b199007bfb::600
dc.date.available2019-09-21T09:03:43Z
dash.workflow.comments1Science Serial ID 27890
dc.identifier.doi10.1016/j.gde.2004.07.010
dash.source.volume14;5
dash.source.page470-476


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