Intakes of vitamins A, C and E and folate and multivitamins and lung cancer: A pooled analysis of 8 prospective studies
View/ Open
38415 guid-053c0728.pdf (111.7Kb)
Access Status
Full text of the requested work is not available in DASH at this time ("dark deposit"). For more information on dark deposits, see our FAQ.Author
Cho, Eunyoung
Hunter, David J.
Spiegelman, Donna
Albanes, Demetrius
Beeson, W. Lawrence
van den Brandt, Piet A.
Colditz, Graham A.
Feskanich, Diane
Folsom, Aaron R.
Fraser, Gary E.
Freudenheim, Jo L.
Giovannucci, Edward
Goldbohm, R. Alexandra
Graham, Saxon
Miller, Anthony B.
Rohan, Thomas E.
Sellers, Thomas A.
Virtamo, Jarmo
Willett, Walter C.::94559ea206eef8a8844fc5b80654fa5b::600
Smith-Warner, Stephanie A.
Published Version
https://doi.org/10.1002/ijc.21441Metadata
Show full item recordCitation
Cho, Eunyoung, David J. Hunter, Donna Spiegelman, Demetrius Albanes, W. Lawrence Beeson, Piet A. van den Brandt, Graham A. Colditz, et al. 2005. “Intakes of Vitamins A, C and E and Folate and Multivitamins and Lung Cancer: A Pooled Analysis of 8 Prospective Studies.” International Journal of Cancer 118 (4): 970–78. https://doi.org/10.1002/ijc.21441.Abstract
Intakes of vitamins A, C and E and folate have been hypothesized to reduce lung cancer risk. We examined these associations in a pooled analysis of the primary data from 8 prospective studies from North America and Europe. Baseline vitamin intake was assessed using a validated food-frequency questionnaire, in each study. We calculated study-specific associations and pooled them using a random-effects model. During follow-up of 430,281 persons over a maximum of 6-16 years in the studies, 3,206 incident lung cancer cases were documented. Vitamin intakes were inversely associated with lung cancer risk in age-adjusted analyses; the associations were greatly attenuated after adjusting for smoking and other risk factors for lung cancer. The pooled multivariate relative risks, comparing the highest vs. lowest quintile of intake from food-only, were 0.96 (95% confidence interval (CI) 0.83-1.11) for vitamin A, 0.80 (95% CI 0.714.91) for vitamin C, 0.86 (95% CI 0.76-0.99) for vitamin E and 0.88 (95% Cl 0.74-1.04) for folate. The association with vitamin C was not independent of our previously reported inverse association with beta-cryptoxanthin. Further, vitamin intakes from foods plus supplements were not associated with a reduced risk of lung cancer in multivariate analyses, and use of multivitamins and specific vitamin supplements was not significantly associated with lung cancer risk. The results generally did not differ across studies or by sex, smoking habits and lung cancer cell type. In conclusion, these data do not support the hypothesis that intakes of vitamins A, C and E and folate reduce lung cancer risk.Citable link to this page
http://nrs.harvard.edu/urn-3:HUL.InstRepos:41384616
Collections
- SPH Scholarly Articles [6392]
Contact administrator regarding this item (to report mistakes or request changes)