Maternal multivitamin supplementation reduces the risk of diarrhoea among HIV-exposed children through age 5 years
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CitationKhavari, Nasim, Hongyu Jiang, Karim Manji, Gernard Msamanga, Donna Spiegelman, Wafaie Fawzi, and Christopher Duggan. 2014. “Maternal Multivitamin Supplementation Reduces the Risk of Diarrhoea among HIV-Exposed Children through Age 5 Years.” International Health 6 (4): 298–305. https://doi.org/10.1093/inthealth/ihu061.
AbstractBackground: The aim of this study was to determine whether maternal vitamin supplementation affects long-term mortality and morbidity of children born to HIV-infected mothers. Methods: In total, 1078 HIV-infected pregnant woman were enrolled in a double-blind, 2x2 factorial, randomised, placebo-controlled trial in Tanzania. Data were collected for 874 children at monthly clinic visits through a median age of 51 months. Results: Maternal receipt of multivitamins (HR=0.93; 95% CI 0.70-1.22) or vitamin A (HR=1.00; 95% CI 0.76-1.32) did not affect all-cause child mortality through age 5 years. Among HIV-negative children, maternal multivitamin supplementation was associated with a lower mortality rate up to 5 years (HR=0.60; 95% CI 0.38-0.95), primarily in children <2 years of age. Maternal vitamin A supplementation did not significantly affect child mortality up to 5 years (HR=0.76; 95% CI 0.48-1.20). Children born to mothers who received multivitamins had a lower risk of all types of diarrhoea (RR=0.86; 95% CI 0.75-0.98) through 5 years of age. The reduced risk of watery diarrhoea persisted in children from 2-5 years of age (RR=0.71; 95% CI 0.54-0.95). Conclusions: Maternal vitamin supplementation during pregnancy and lactation may be associated with long-lasting affects in HIV-exposed children
Citable link to this pagehttp://nrs.harvard.edu/urn-3:HUL.InstRepos:41384624
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