Heterogeneity of Risk Factors and Antibody Profiles in Epstein‐Barr Virus Genome–Positive and –Negative Hodgkin Lymphoma
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Chang, Ellen T.
Lennette, Evelyne T.
Weir, Edward G.
Mann, Risa B.
Mueller, Nancy E.
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CitationChang, Ellen T., Tongzhang Zheng, Evelyne T. Lennette, Edward G. Weir, Michael Borowitz, Risa B. Mann, Donna Spiegelman, and Nancy E. Mueller. 2004. “Heterogeneity of Risk Factors and Antibody Profiles in Epstein‐Barr Virus Genome–Positive and –Negative Hodgkin Lymphoma.” The Journal of Infectious Diseases 189 (12): 2271–81. https://doi.org/10.1086/420886.
AbstractBackground. Hodgkin lymphoma (HL) tumors that contain the Epstein-Barr virus (EBV) genome may differ etiologically from EBV-negative HL tumors.Methods. A case-case study examining heterogeneity of risk factors between disease subgroups compared personal characteristics and EBV antibodies between 95 EBV-positive and 303 EBV-negative patients with HL. Results. We confirmed previous associations of EBV-positive HL with older age, male sex, and mixed-cellularity ( MC) histological subtypes. EBV-positive patients were less educated and more likely to have smoked cigarettes and had more prevalent and higher EBV antibody titers, compared with EBV-negative patients. After adjustment for all independent risk factors, those most strongly associated with EBV-positive HL were histological subtypes (odds ratio [OR] for MC vs. nodular sclerosis histology, 3.2; 95% confidence interval [CI], 1.4-7.2), elevated anti viral capsid antigen level (OR, 3.1; 95% CI, 1.6-6.0), and less education (OR, 0.7; 95% CI, 0.5-1.0). Cigarette smoking and a low anti-Epstein- Barr nuclear protein (EBNA) 1: anti-EBNA-2 ratio were also marginally associated with EBV-positive HL. Conclusions. EBV-positive HL is more common among individuals who have markers of diminished cellular immunity and an abnormal EBV antibody response. EBV appears to participate in the etiology of EBV-positive HL but may not be involved in EBV-negative HL.
Citable link to this pagehttp://nrs.harvard.edu/urn-3:HUL.InstRepos:41384625
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