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dc.contributor.authorChang, Ellen T.
dc.contributor.authorZheng, Tongzhang
dc.contributor.authorLennette, Evelyne T.
dc.contributor.authorWeir, Edward G.
dc.contributor.authorBorowitz, Michael
dc.contributor.authorMann, Risa B.
dc.contributor.authorSpiegelman, Donna
dc.contributor.authorMueller, Nancy E.
dc.date.accessioned2019-09-21T16:10:24Z
dc.date.issued2004
dc.identifier.citationChang, Ellen T., Tongzhang Zheng, Evelyne T. Lennette, Edward G. Weir, Michael Borowitz, Risa B. Mann, Donna Spiegelman, and Nancy E. Mueller. 2004. “Heterogeneity of Risk Factors and Antibody Profiles in Epstein‐Barr Virus Genome–Positive and –Negative Hodgkin Lymphoma.” The Journal of Infectious Diseases 189 (12): 2271–81. https://doi.org/10.1086/420886.
dc.identifier.issn0022-1899
dc.identifier.issn1537-6613
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:41384625*
dc.description.abstractBackground. Hodgkin lymphoma (HL) tumors that contain the Epstein-Barr virus (EBV) genome may differ etiologically from EBV-negative HL tumors.Methods. A case-case study examining heterogeneity of risk factors between disease subgroups compared personal characteristics and EBV antibodies between 95 EBV-positive and 303 EBV-negative patients with HL. Results. We confirmed previous associations of EBV-positive HL with older age, male sex, and mixed-cellularity ( MC) histological subtypes. EBV-positive patients were less educated and more likely to have smoked cigarettes and had more prevalent and higher EBV antibody titers, compared with EBV-negative patients. After adjustment for all independent risk factors, those most strongly associated with EBV-positive HL were histological subtypes (odds ratio [OR] for MC vs. nodular sclerosis histology, 3.2; 95% confidence interval [CI], 1.4-7.2), elevated anti viral capsid antigen level (OR, 3.1; 95% CI, 1.6-6.0), and less education (OR, 0.7; 95% CI, 0.5-1.0). Cigarette smoking and a low anti-Epstein- Barr nuclear protein (EBNA) 1: anti-EBNA-2 ratio were also marginally associated with EBV-positive HL. Conclusions. EBV-positive HL is more common among individuals who have markers of diminished cellular immunity and an abnormal EBV antibody response. EBV appears to participate in the etiology of EBV-positive HL but may not be involved in EBV-negative HL.
dc.language.isoen_US
dc.publisherOxford University Press
dash.licenseMETA_ONLY
dc.titleHeterogeneity of Risk Factors and Antibody Profiles in Epstein‐Barr Virus Genome–Positive and –Negative Hodgkin Lymphoma
dc.typeJournal Article
dc.description.versionVersion of Record
dc.relation.journalThe Journal of Infectious Diseases
dash.depositing.authorSpiegelman, Donna::37eeac21962b33e4e46e7aedde542849::600
dc.date.available2019-09-21T16:10:24Z
dash.workflow.comments1Science Serial ID 107934
dc.identifier.doi10.1086/420886
dash.source.volume189;12
dash.source.page2271-2281


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