Study design and methods for a randomized crossover trial substituting brown rice for white rice on diabetes risk factors in India
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Author
Wedick, Nicole
Vasudevan, Sudha
Spiegelman, Donna
Bai, Ramya
Malik, Vasanti
Venkatachalam, Siva Sankari
Parthasarathy, Vijayalaksmi
Vaidya, Ruchi
Nagarajan, Lakshmipriya
Arumugam, Kokila
Jones, Clara
Campos, Hannia
Krishnaswamy, Kamala
Willett, Walter C.::94559ea206eef8a8844fc5b80654fa5b::600
Hu, Frank
Mohan, Anjana Ranjit
Viswanathan, Mohan
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https://doi.org/10.3109/09637486.2015.1038225Metadata
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Wedick, Nicole M., Vasudevan Sudha, Donna Spiegelman, Mookambika Ramya Bai, Vasanti S. Malik, Siva Sankari Venkatachalam, Vijayalaksmi Parthasarathy, et al. 2015. “Study Design and Methods for a Randomized Crossover Trial Substituting Brown Rice for White Rice on Diabetes Risk Factors in India.” International Journal of Food Sciences and Nutrition 66 (7): 797–804. https://doi.org/10.3109/09637486.2015.1038225.Abstract
India has the second largest number of people with diabetes in the world following China. Evidence indicates that consumption of whole grains can reduce the risk of type 2 diabetes. This article describes the study design and methods of a trial in progress evaluating the effects of substituting whole grain brown rice for polished (refined) white rice on biomarkers of diabetes risk (glucose metabolism, dyslipidemia, inflammation). This is a randomized controlled clinical trial with a crossover design conducted in Chennai, India among overweight but otherwise healthy volunteers aged 25-65y with a body mass index >= 23 kg/m(2) and habitual rice consumption >= 200 g/day. The feasibility and cultural appropriateness of this type of intervention in the local environment will also be examined. If the intervention is efficacious, the findings can be incorporated into national-level policies which could include the provision of brown rice as an option or replacement for white rice in government institutions and food programs. This relatively simple dietary intervention has the potential to substantially diminish the burden of diabetes in Asia and elsewhere.Terms of Use
This article is made available under the terms and conditions applicable to Open Access Policy Articles, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#OAPCitable link to this page
http://nrs.harvard.edu/urn-3:HUL.InstRepos:41384629
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