Dietary Fiber Intake and Risk of Colorectal Cancer: A Pooled Analysis of Prospective Cohort Studies
View/ Open
44261 guid-1d7030e0.pdf (146.8Kb)
Access Status
Full text of the requested work is not available in DASH at this time ("restricted access"). For more information on restricted deposits, see our FAQ.Author
Park, Yikyung
Hunter, David
Spiegelman, Donna
Bergkvist, Leif
Berrino, Franco
Van Den Brandt, Piet
Buring, Julie
Colditz, Graham
Freudenheim, Jo
Fuchs, Charles
Giovannucci, Edward
Goldbohm, R.
Graham, Saxon
Harnack, Lisa
Hartman, Anne
Jacobs, David
Kato, Ikuko
Krogh, Vittorio
Leitzmann, Michael
Mccullough, Marjorie
Miller, Anthony
Pietinen, Pirjo
Rohan, Thomas
Schatzkin, Arthur
Willett, Walter C.::94559ea206eef8a8844fc5b80654fa5b::600
Wolk, Alicja
Zeleniuch-Jacquotte, Anne
Zhang, Shumin
Smith-Warner, Stephanie
Published Version
https://doi.org/10.1001/jama.294.22.2849Metadata
Show full item recordCitation
Park, Yikyung, David J. Hunter, Donna Spiegelman, Leif Bergkvist, Franco Berrino, Piet A. van den Brandt, Julie E. Buring, et al. 2005. “Dietary Fiber Intake and Risk of Colorectal Cancer.” JAMA 294 (22): 2849. https://doi.org/10.1001/jama.294.22.2849.Abstract
Context Inconsistent findings from observational studies have continued the controversy over the effects of dietary fiber on colorectal cancer. Objective: To evaluate the association between dietary fiber intake and risk of colorectal cancer. Design, Setting, and Participants From 13 prospective cohort studies included in the Pooling Project of Prospective Studies of Diet and Cancer, 725 628 men and women were followed up for 6 to 20 years across studies. Study- and sex-specific relative risks (RRs) were estimated with the Cox proportional hazards model and were subsequently pooled using a random-effects model. Main Outcome Measure Incident colorectal cancer. Results: During 6 to 20 years of follow-up across studies, 8081 colorectal cancer cases were identified. For comparison of the highest vs lowest study- and sex-specific quintile of dietary fiber intake, a significant inverse association was found in the age-adjusted model (pooled RR=0.84; 95% confidence interval [CI], 0.77-0.92). However, the association was attenuated and no longer statistically significant after adjusting for other risk factors (pooled multivariate RR=0.94; 95% Cl, 0.86-1.03). In categorical analyses compared with dietary fiber intake of 10 to <15 g/d, the pooled multivariate RR was 1.18 (95% Cl, 1.05-1.31) for less than 10 g/d (11% of the overall study population); and RR, 1.00 (95% Cl, 0.85-1.17) for 30 or more g/d. Fiber intake from cereals, fruits, and vegetables was not associated with risk of colorectal cancer. The pooled multivariate RRs comparing the highest vs lowest study- and sex-specific quintile of dietary fiber intake were 1.00 (95% Cl, 0.90-1.11) for colon cancer and 0.85 (95% Cl, 0.72-1.01) for rectal cancer (P for common effects by tumor site=.07). Conclusions: In this large pooled analysis, dietary fiber intake was inversely associated with risk of colorectal cancer in age-adjusted analyses. However, after accounting for other dietary risk factors, high dietary fiber intake was not associated with a reduced risk of colorectal cancer.Citable link to this page
http://nrs.harvard.edu/urn-3:HUL.InstRepos:41384641
Collections
- SPH Scholarly Articles [6351]
Contact administrator regarding this item (to report mistakes or request changes)