Dietary intake of vitamin D during adolescence and risk of multiple sclerosis
View/ Open
Author
Munger, Kassandra L.
Chitnis, Tanuja
Frazier, A. Lindsay
Giovannucci, Edward
Spiegelman, Donna
Ascherio, Alberto
Published Version
https://doi.org/10.1007/s00415-010-5783-1Metadata
Show full item recordCitation
Munger, Kassandra L., Tanuja Chitnis, A. Lindsay Frazier, Edward Giovannucci, Donna Spiegelman, and Alberto Ascherio. 2010. “Dietary Intake of Vitamin D during Adolescence and Risk of Multiple Sclerosis.” Journal of Neurology 258 (3): 479–85. https://doi.org/10.1007/s00415-010-5783-1.Abstract
Adolescence may be an important etiological period in the development of multiple sclerosis (MS), and studies suggest that adequate vitamin D nutrition is protective. Here, the authors examined whether dietary intake of vitamin D during adolescence decreases the risk of MS in adulthood. In 1986 in the Nurses' Health Study and in 1998 in the Nurses' Health Study II (NHSII), women completed a food frequency questionnaire regarding their dietary intake during adolescence. From this, daily intake of vitamin D was calculated. Adolescent diet was available for 379 incident MS cases confirmed over the combined 44 years of follow-up in both cohorts, and for 67 prevalent cases in the NHSII who had MS at baseline (1989). Cox proportional hazards models were used to calculate relative risk estimates and 95% confidence intervals. Total vitamin D intake during adolescence was not associated with MS risk. Intake of a parts per thousand yen400 IU/day of vitamin D from multivitamins was associated with a non-statistically significant reduced risk (RR compared to no intake = 0.73, 95% CI: 0.50-1.07, P = 0.11), whereas intake of whole milk, an important source of dietary vitamin D, was associated with an increased risk. The possibility of opposite effects of vitamin D and milk intake on MS risk should be considered in future studies.Terms of Use
This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAACitable link to this page
http://nrs.harvard.edu/urn-3:HUL.InstRepos:41384656
Collections
- SPH Scholarly Articles [6362]
Contact administrator regarding this item (to report mistakes or request changes)