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dc.contributor.authorZhang, Xuehong
dc.contributor.authorSpiegelman, Donna
dc.contributor.authorBaglietto, Laura
dc.contributor.authorBernstein, Leslie
dc.contributor.authorBoggs, Deborah
dc.contributor.authorvan den Brandt, Piet A.
dc.contributor.authorBuring, Julie
dc.contributor.authorGapstur, Susan
dc.contributor.authorGiles, Graham
dc.contributor.authorGiovannucci, Edward
dc.contributor.authorGoodman, Gary
dc.contributor.authorHankinson, Susan
dc.contributor.authorHelzlsouer, Kathy
dc.contributor.authorHorn-Ross, Pamela
dc.contributor.authorInoue, Manami
dc.contributor.authorJung, Seungyoun
dc.contributor.authorKhudyakov, Polyna
dc.contributor.authorLarsson, Susanna
dc.contributor.authorLof, Marie
dc.contributor.authorMcCullough, Marjorie
dc.contributor.authorMiller, Anthony
dc.contributor.authorNeuhouser, Marian
dc.contributor.authorPalmer, Julie
dc.contributor.authorPark, Yikyung
dc.contributor.authorRobien, Kim
dc.contributor.authorRohan, Thomas
dc.contributor.authorRoss, Julie
dc.contributor.authorSchouten, Leo
dc.contributor.authorShikany, James
dc.contributor.authorTsugane, Shoichiro
dc.contributor.authorVisvanathan, Kala
dc.contributor.authorWeiderpass, Elisabete
dc.contributor.authorWolk, Alicja
dc.contributor.authorWillett, Walter C.::94559ea206eef8a8844fc5b80654fa5b::600
dc.contributor.authorZhang, Shumin
dc.contributor.authorZiegler, Regina
dc.contributor.authorSmith-Warner, Stephanie
dc.date.accessioned2019-09-21T16:11:22Z
dc.date.issued2012
dc.identifier.citationZhang, Xuehong, Donna Spiegelman, Laura Baglietto, Leslie Bernstein, Deborah A Boggs, Piet A van den Brandt, Julie E Buring, et al. 2012. “Carotenoid Intakes and Risk of Breast Cancer Defined by Estrogen Receptor and Progesterone Receptor Status: A Pooled Analysis of 18 Prospective Cohort Studies.” The American Journal of Clinical Nutrition 95 (3): 713–25. https://doi.org/10.3945/ajcn.111.014415.
dc.identifier.issn0002-9165
dc.identifier.issn1938-3207
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:41384703*
dc.description.abstractBackground: Epidemiologic studies examining associations between carotenoid intakes and risk of breast cancer by estrogen receptor (ER) and progesterone receptor (PR) status are limited. Objective: We investigated these associations in a pooled analysis of 18 cohort studies. Design: Of 1,028,438 participants followed for a maximum follow-up of 26 y across studies, 33,380 incident invasive breast cancers were identified. Study-specific RRs and 95% CIs were estimated by using Cox proportional hazards regression and then pooled by using a random-effects model. Results: alpha-Carotene, beta-carotene, and lutein/zeaxanthin intakes were inversely associated with the risk of ER-negative (ER-) breast cancer (pooled multivariable RRs of the comparison between the highest and lowest quintiles): alpha-carotene (0.87; 95% CI: 0.78, 0.97), beta-carotene (0.84; 95% CI: 0.77, 0.93), and lutein/zeaxanthin (0.87; 95% CI: 0.79, 0.95). These variables were not inversely associated with the risk of ER-positive (ER+) breast cancer (pooled multivariable RRs for the same comparison): a-carotene (1.04; 95% CI: 0.99, 1.09), beta-carotene (1.04; 95% CI: 0.98, 1.10), and lutein/zeaxanthin (1.00; 95% CI: 0.93, 1.07). Although the pooled RRs for quintile 5 for beta-cryptoxanthin were not significant, inverse trends were observed for ER- and ER+ breast cancer (P-trend <= 0.05). Nonsignificant associations were observed for lycopene intake. The associations were largely not appreciably modified by several breast cancer risk factors. Nonsignificant associations were observed for PR-positive and PR-negative breast cancer. Conclusions: Intakes of alpha-carotene, beta-carotene, and lutein/zeaxanthin were inversely associated with risk of ER-, but not ER+, breast cancer. However, the results need to be interpreted with caution because it is unclear whether the observed association is real or due to other constituents in the same food sources. Am J Clin Nutr 2012;95:713-25.
dc.language.isoen_US
dc.publisherOxford University Press
dash.licenseMETA_ONLY
dc.titleCarotenoid intakes and risk of breast cancer defined by estrogen receptor and progesterone receptor status: a pooled analysis of 18 prospective cohort studies
dc.typeJournal Article
dc.description.versionVersion of Record
dc.relation.journalAmerican Journal of Clinical Nutrition
dash.depositing.authorSpiegelman, Donna::37eeac21962b33e4e46e7aedde542849::600
dc.date.available2019-09-21T16:11:22Z
dash.workflow.comments1Science Serial ID 7149
dc.identifier.doi10.3945/ajcn.111.014415
dash.source.volume95;3
dash.source.page713


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