Show simple item record

dc.contributor.authorAdebamowo, Sally
dc.contributor.authorSpiegelman, Donna
dc.contributor.authorWillett, Walter C.::94559ea206eef8a8844fc5b80654fa5b::600
dc.contributor.authorRexrode, Kathryn
dc.date.accessioned2019-09-21T16:11:22Z
dc.date.issued2015
dc.identifier.citationAdebamowo, Sally N, Donna Spiegelman, Walter C Willett, and Kathryn M Rexrode. 2015. “Association between Intakes of Magnesium, Potassium, and Calcium and Risk of Stroke: 2 Cohorts of US Women and Updated Meta-Analyses.” The American Journal of Clinical Nutrition 101 (6): 1269–77. https://doi.org/10.3945/ajcn.114.100354.
dc.identifier.issn0002-9165
dc.identifier.issn1938-3207
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:41384704*
dc.description.abstractBackground: Prospective data on the relation of magnesium, potassium, and calcium intakes with stroke risk are inconsistent, and to our knowledge, the effect of a combined mineral diet score has not been examined. Objective: We examined associations between intakes of magnesium, potassium, and calcium and risk of incident stroke in 86,149 women in the Nurses' Health Study (NHS) I and 94,715 women in the NHS II. Design: In this prospective cohort study, we calculated HRs of stroke by quintiles of intake for each mineral and for a combined diet score of all 3 minerals by using multivariate Cox proportional hazard models. In addition, we updated meta-analyses on dietary intakes of these minerals and risk of stroke. Results: During follow-up (30 y in the NHS I; 22 y in the NHS II) a total of 3780 incident stroke cases were documented. Pooled multivariate RRs of total stroke for women in the highest compared with the lowest quintiles were 0.87 (95% CI: 0.78, 0.97) for total magnesium, 0.89 (95% CI: 0.80, 0.99) for total potassium, and 0.97 (95% CI: 0.87, 1.09) for total calcium intake. Pooled RRs for women in the highest compared with the lowest quintiles of a combined mineral diet score were 0.72 (95% CI: 0.65, 0.81) for total stroke, 0.78 (95% CI: 0.66, 0.92) for ischemic stroke, and 0.80 (95% CI: 0.61, 1.04) for hemorrhagic stroke. In the updated meta-analyses of all prospective studies to date, the combined RR of total stroke was 0.87 (95% CI: 0.83, 0.92) for a 100-mg/d increase in magnesium intake, 0.91 (95% CI: 0.88, 0.94) for a 1000-mg/d increase in potassium intake, and 0.98 (95% CI: 0.94, 1.02) for a 300-mg/d increase in calcium intake. Conclusions: A combined mineral diet score was inversely associated with risk of stroke. High intakes of magnesium and potassium but not calcium were also significantly associated with reduced risk of stroke in women.
dc.language.isoen_US
dc.publisherOxford University Press
dash.licenseMETA_ONLY
dc.titleAssociation between intakes of magnesium, potassium, and calcium and risk of stroke: 2 cohorts of US women and updated meta-analyses
dc.typeJournal Article
dc.description.versionVersion of Record
dc.relation.journalAmerican Journal of Clinical Nutrition
dash.depositing.authorSpiegelman, Donna::37eeac21962b33e4e46e7aedde542849::600
dc.date.available2019-09-21T16:11:22Z
dash.workflow.comments1Science Serial ID 7209
dc.identifier.doi10.3945/ajcn.114.100354
dash.source.volume101;6
dash.source.page1269


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record