Vitamin D Status and its Association with Morbidity Including Wasting and Opportunistic Illnesses in HIV-Infected Women in Tanzania
View/ Open
8303 apc.2011.0182.pdf (277.4Kb)
Access Status
Full text of the requested work is not available in DASH at this time ("restricted access"). For more information on restricted deposits, see our FAQ.Author
Mehta, Saurabh
Mugusi, Ferdinand M.
Spiegelman, Donna
Villamor, Eduardo
Finkelstein, Julia L.
Hertzmark, Ellen
Giovannucci, Edward L.
Msamanga, Gernard I.
Fawzi, Wafaie W.
Published Version
https://doi.org/10.1089/apc.2011.0182Metadata
Show full item recordCitation
Mehta, Saurabh, Ferdinand M. Mugusi, Donna Spiegelman, Eduardo Villamor, Julia L. Finkelstein, Ellen Hertzmark, Edward L. Giovannucci, Gernard I. Msamanga, and Wafaie W. Fawzi. 2011. “Vitamin D Status and Its Association with Morbidity Including Wasting and Opportunistic Illnesses in HIV-Infected Women in Tanzania.” AIDS Patient Care and STDs 25 (10): 579–85. https://doi.org/10.1089/apc.2011.0182.Abstract
Vitamin D has a potential role in preventing HIV-related complications, based on its extensive involvement in immune and metabolic function, including preventing osteoporosis and premature cardiovascular disease. However, this association has not been examined in large studies or in resource-limited settings. Vitamin D levels were assessed in 884 HIV-infected pregnant women at enrollment in a trial of multivitamin supplementation (excluding vitamin D) in Tanzania. Information on HIV related complications was recorded during follow-up (median, 70 months). Proportional hazards models and generalized estimating equations were used to assess the relationship of vitamin D status with these outcomes. Women with low vitamin D status (serum 25-hydroxyvitamin D<32 ng/mL) had 43% higher risk of reaching a body mass index (BMI) less than 18 kg/m(2) during the first 2 years of follow-up, compared to women with adequate vitamin D levels (hazard ratio [HR]: 1.43; 95% confidence intervals: [1.03-1.99]). The relationship between continuous vitamin D levels and risk of BMI less than 18 kg/m(2) during follow-up was inverse and linear (p = 0.03). Women with low vitamin D levels had significantly higher incidence of acute upper respiratory infections (HR: 1.27 [1.04-1.54]) and thrush (HR: 2.74 [1.29-5.83]) diagnosed during the first 2 years of follow-up. Low vitamin D status was a significant risk factor for wasting and HIV-related complications such as thrush during follow-up in this prospective cohort in Tanzania. If these protective associations are confirmed in randomized trials, vitamin D supplementation could represent a simple and inexpensive method to improve health and quality of life of HIV-infected patients, particularly in resource-limited settings.Citable link to this page
http://nrs.harvard.edu/urn-3:HUL.InstRepos:41384728
Collections
- SPH Scholarly Articles [6399]
Contact administrator regarding this item (to report mistakes or request changes)