Weight and body composition in a cohort of HIV-positive men and women
Forrester, J. E.
Knox, T. A.
Fauntleroy, J. M.
Gorbach, S. L.
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CitationForrester, JE, D Spiegelman, M Woods, TA Knox, JM Fauntleroy, and SL Gorbach. 2001. “Weight and Body Composition in a Cohort of HIV-Positive Men and Women.” Public Health Nutrition 4 (3): 743–47. https://doi.org/10.1079/phn200099.
AbstractObjective. At issue is whether weight loss in HIV infection is a cachectic process, characterised by loss of lean body mass with conservation of fat, or a process of starvation. We present data on body composition from 516 persons at different stages of HIV infection as determined by CD4 counts. Design: Cross-sectional analyses of body composition in relation to CD4 count. Setting: The baseline data from a prospective cohort study of outcomes in HIV/AIDS in relation to nutritional status in Boston, Massachusetts, USA.Subjects: The first 516 subjects with HIV/AIDS to enrol in the study. Results: Differences in weight in relation to CD4 counts were present only at CD4 counts of 600 or less (slope below CD4 = 600: 1.9 kg per 100 CD4 cells, P < 0.0001). On average, 68% of the difference in weight over CD4 counts was fat (slope: 1.3 kg fat per 100 CD4 cells, P < 0.0001). Conclusions: This cross-sectional analysis suggests that weight loss consists principally of fat loss in those persons with adequate fat stores. This observation will need to be confirmed in longitudinal analyses.
Citable link to this pagehttp://nrs.harvard.edu/urn-3:HUL.InstRepos:41384731
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