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dc.contributor.authorLee, J. E.
dc.contributor.authorGiovannucci, E.
dc.contributor.authorSmith-Warner, S. A.
dc.contributor.authorSpiegelman, D.
dc.contributor.authorWillett, Walter C.::94559ea206eef8a8844fc5b80654fa5b::600
dc.contributor.authorCurhan, G. C.
dc.date.accessioned2019-09-21T16:12:02Z
dc.date.issued2006
dc.identifier.citationLee, J. E., E. Giovannucci, S. A. Smith-Warner, D. Spiegelman, W. C. Willett, and G. C. Curhan. 2006. “Intakes of Fruits, Vegetables, Vitamins A, C, and E, and Carotenoids and Risk of Renal Cell Cancer.” Cancer Epidemiology Biomarkers & Prevention 15 (12): 2445–52. https://doi.org/10.1158/1055-9965.epi-06-0553.
dc.identifier.issn1055-9965
dc.identifier.issn1538-7755
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:41384753*
dc.description.abstractBackground: Fruits and vegetables rich in antioxidants have been proposed to reduce the risk of renal cell cancer. However, few prospective studies have examined the intakes of fruits, vegetables, and antioxidant vitamins in relation to the risk of renal cell cancer. Methods: We prospectively examined the associations between the intakes of fruits, vegetables, vitamins A, C, and E, and carotenoids and risk of renal cell cancer in women and men. We followed 88,759 women in the Nurses' Health Study from 1980 to 2000, and 47,828 men in the Health Professionals Follow-up Study from 1986 to 2000. We assessed dietary intake every 2 to 4 years using a validated semiquantitative food frequency questionnaire. The Cox proportional hazards model was used to estimate study-specific multivariate relative risks (RR), which were pooled using a random effects model. Results: A total of 248 (132 women and 116 men) incident renal cell cancer cases were ascertained during 2,316,525 person-years of follow-up. The consumption of fruits and vegetables was associated with a decreased risk of renal cell cancer in men (multivariate RR, 0.45; 95% Cl, 0.25-0.81, for >= 6 servings of fruit and vegetable intake/d versus < 3 servings/d; P test for trend =0.02), but not in women (multivariate RR, 1.17; 95% CI, 0.66-2.07, for the same contrast; P test for trend =0.25; P test for between-studies heterogeneity =0.02). Intakes of vitamins A and C from food and carotenoids were inversely associated with the risk of renal cell cancer in men only, but we cannot exclude the possibility that this was due to other factors in fruit and vegetables. No clear association was observed for vitamin E in women or men. Conclusions: Fruit and vegetable consumption may reduce the risk of renal cell cancer in men.
dc.language.isoen_US
dc.publisherAmerican Association for Cancer Research
dash.licenseMETA_ONLY
dc.titleIntakes of Fruits, Vegetables, Vitamins A, C, and E, and Carotenoids and Risk of Renal Cell Cancer
dc.typeJournal Article
dc.description.versionVersion of Record
dc.relation.journalCancer Epidemiology, Biomarkers & Prevention
dash.depositing.authorSpiegelman, Donna::37eeac21962b33e4e46e7aedde542849::600
dc.date.available2019-09-21T16:12:02Z
dash.workflow.comments1Science Serial ID 18446
dc.identifier.doi10.1158/1055-9965.EPI-06-0553
dash.source.volume15;12
dash.source.page2445-2452


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