Effect of Providing Vitamin Supplements to Human Immunodeficiency Virus–Infected, Lactating Mothers on the Child's Morbidity and CD4 + Cell Counts
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Fawzi, Wafaie W.
Msamanga, Gernard I.
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CitationFawzi, Wafaie W., Gernard I. Msamanga, Ruilan Wei, Donna Spiegelman, Gretchen Antelman, Eduardo Villamor, Karim Manji, and David Hunter. 2003. “Effect of Providing Vitamin Supplements to Human Immunodeficiency Virus–Infected, Lactating Mothers on the Child’s Morbidity and CD4+Cell Counts.” Clinical Infectious Diseases 36 (8): 1053–62. https://doi.org/10.1086/374223.
AbstractA total of 1078 human immunodeficiency virus (HIV) type 1-infected women from Tanzania were randomized in a placebo-controlled trial using a factorial design to examine the effects of supplementation with vitamin A (preformed vitamin A and beta carotene) and/or multivitamins (vitamins B, C, and E). Supplements were given during pregnancy and lactation. Children of women in the multivitamin arms had a significantly lower risk of diarrhea than did those in the no-multivitamin arm (P=.03). The mean CD4(+) cell count was 151 cells/muL higher among children in the multivitamin arms than among those in the no-multivitamin arm (P=.0006). HIV-positive children experienced a benefit apparently similar to that in HIV-negative children (P=.34, by test for interaction). Maternal receipt of vitamin A significantly reduced the risk that the child would have cough with a rapid respiratory rate, a proxy for pneumonia (P=.03), but receipt of vitamin A had no effect on diarrhea or CD4(+) cell count. Provision of multivitamin supplements ( including those with vitamins B, C, and E) to HIV-infected, lactating women may be a low-cost intervention to improve their children's health.
Citable link to this pagehttp://nrs.harvard.edu/urn-3:HUL.InstRepos:41384769
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