dc.contributor.author | Kim, Dong-Hyun | |
dc.contributor.author | Smith-Warner, Stephanie A. | |
dc.contributor.author | Spiegelman, Donna | |
dc.contributor.author | Yaun, Shiaw-Shyuan | |
dc.contributor.author | Colditz, Graham A. | |
dc.contributor.author | Freudenheim, Jo L. | |
dc.contributor.author | Giovannucci, Edward | |
dc.contributor.author | Goldbohm, R. Alexandra | |
dc.contributor.author | Graham, Saxon | |
dc.contributor.author | Harnack, Lisa | |
dc.contributor.author | Jacobs, Eric J. | |
dc.contributor.author | Leitzmann, Michael | |
dc.contributor.author | Mannisto, Satu | |
dc.contributor.author | Miller, Anthony B. | |
dc.contributor.author | Potter, John D. | |
dc.contributor.author | Rohan, Thomas E. | |
dc.contributor.author | Schatzkin, Arthur | |
dc.contributor.author | Speizer, Frank E. | |
dc.contributor.author | Stevens, Victoria L. | |
dc.contributor.author | Stolzenberg-Solomon, Rachael | |
dc.contributor.author | Terry, Paul | |
dc.contributor.author | Toniolo, Paolo | |
dc.contributor.author | Weijenberg, Matty P. | |
dc.contributor.author | Willett, Walter C.::94559ea206eef8a8844fc5b80654fa5b::600 | |
dc.contributor.author | Wolk, Alicja | |
dc.contributor.author | Zeleniuch-Jacquotte, Anne | |
dc.contributor.author | Hunter, David J. | |
dc.date.accessioned | 2019-09-21T16:12:20Z | |
dc.date.issued | 2010 | |
dc.identifier.citation | Kim, Dong-Hyun, Stephanie A. Smith-Warner, Donna Spiegelman, Shiaw-Shyuan Yaun, Graham A. Colditz, Jo L. Freudenheim, Edward Giovannucci, et al. 2010. “Pooled Analyses of 13 Prospective Cohort Studies on Folate Intake and Colon Cancer.” Cancer Causes & Control 21 (11): 1919–30. https://doi.org/10.1007/s10552-010-9620-8. | |
dc.identifier.issn | 0957-5243 | |
dc.identifier.issn | 1573-7225 | |
dc.identifier.uri | http://nrs.harvard.edu/urn-3:HUL.InstRepos:41384774 | * |
dc.description.abstract | Studies of folate intake and colorectal cancer risk have been inconsistent. We examined the relation with colon cancer risk in a series of 13 prospective studies.Study- and sex-specific relative risks (RRs) were estimated from the primary data using Cox proportional hazards models and then pooled using a random-effects model.Among 725,134 participants, 5,720 incident colon cancers were diagnosed during follow-up. The pooled multivariate RRs (95% confidence interval [CI]) comparing the highest vs. lowest quintile of intake were 0.92 (95% CI 0.84-1.00, p-value, test for between-studies heterogeneity = 0.85) for dietary folate and 0.85 (95% CI 0.77-0.95, p-value, test for between-studies heterogeneity = 0.42) for total folate. Results for total folate intake were similar in analyses using absolute intake cutpoints (pooled multivariate RR = 0.87, 95% CI 0.78-0.98, comparing a parts per thousand yen560 mcg/days vs. < 240 mcg/days, p-value, test for trend = 0.009). When analyzed as a continuous variable, a 2% risk reduction (95% CI 0-3%) was estimated for every 100 mu g/day increase in total folate intake.These data support the hypothesis that higher folate intake is modestly associated with reduced risk of colon cancer. | |
dc.language.iso | en_US | |
dc.publisher | Springer (part of Springer Nature) | |
dash.license | LAA | |
dc.title | Pooled analyses of 13 prospective cohort studies on folate intake and colon cancer | |
dc.type | Journal Article | |
dc.description.version | Accepted Manuscript | |
dc.relation.journal | Cancer Causes and Control | |
dash.depositing.author | Spiegelman, Donna::37eeac21962b33e4e46e7aedde542849::600 | |
dc.date.available | 2019-09-21T16:12:20Z | |
dash.workflow.comments | 1Science Serial ID 22810 | |
dc.identifier.doi | 10.1007/s10552-010-9620-8 | |
dash.source.volume | 21;11 | |
dash.source.page | 1919 | |