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dc.contributor.authorMachiela, Mitchell
dc.contributor.authorLan, Qing
dc.contributor.authorSlager, Susan
dc.contributor.authorVermeulen, Roel C. H.
dc.contributor.authorTeras, Lauren
dc.contributor.authorCamp, Nicola
dc.contributor.authorCerhan, James
dc.contributor.authorSpinelli, John
dc.contributor.authorWang, Sophia
dc.contributor.authorNieters, Alexandra
dc.contributor.authorVijai, Joseph
dc.contributor.authorYeager, Meredith
dc.contributor.authorWang, Zhaoming
dc.contributor.authorHervé Ghesquières
dc.contributor.authorMcKay, James
dc.contributor.authorConde, Lucia
dc.contributor.authorde Bakker, Paul I. W.
dc.contributor.authorCox, David
dc.contributor.authorBurdett, Laurie
dc.contributor.authorMonnereau, Alain
dc.contributor.authorFlowers, Christopher
dc.contributor.authorDe Roos, Anneclaire J.
dc.contributor.authorBrooks-Wilson, Angela
dc.contributor.authorGiles, Graham
dc.contributor.authorMelbye, Mads
dc.contributor.authorGu, Jian
dc.contributor.authorJackson, Rebecca
dc.contributor.authorKane, Eleanor
dc.contributor.authorPurdue, Mark
dc.contributor.authorVajdic, Claire
dc.contributor.authorAlbanes, Demetrius
dc.contributor.authorKelly, Rachel
dc.contributor.authorZucca, Mariagrazia
dc.contributor.authorBertrand, Kimberly
dc.contributor.authorZeleniuch-Jacquotte, Anne
dc.contributor.authorLawrence, Charles
dc.contributor.authorHutchinson, Amy
dc.contributor.authorZhi, Degui
dc.contributor.authorHabermann, Thomas
dc.contributor.authorLink, Brian
dc.contributor.authorNovak, Anne
dc.contributor.authorDogan, Ahmet
dc.contributor.authorAsmann, Yan
dc.contributor.authorLiebow, Mark
dc.contributor.authorThompson, Carrie
dc.contributor.authorAnsell, Stephen
dc.contributor.authorWitzig, Thomas
dc.contributor.authorHervé Tilly
dc.contributor.authorHaioun, Corinne
dc.contributor.authorMolina, Thierry
dc.contributor.authorHjalgrim, Henrik
dc.contributor.authorGlimelius, Bengt
dc.contributor.authorAdami, Hans-Olov
dc.contributor.authorGöran Roos
dc.contributor.authorBracci, Paige
dc.contributor.authorRiby, Jacques
dc.contributor.authorSmith, Martyn
dc.contributor.authorHolly, Elizabeth
dc.contributor.authorCozen, Wendy
dc.contributor.authorHartge, Patricia
dc.contributor.authorMorton, Lindsay
dc.contributor.authorSeverson, Richard
dc.contributor.authorTinker, Lesley
dc.contributor.authorNorth, Kari
dc.contributor.authorBecker, Nikolaus
dc.contributor.authorBenavente, Yolanda
dc.contributor.authorBoffetta, Paolo
dc.contributor.authorBrennan, Paul
dc.contributor.authorForetova, Lenka
dc.contributor.authorMaynadie, Marc
dc.contributor.authorStaines, Anthony
dc.contributor.authorLightfoot, Tracy
dc.contributor.authorCrouch, Simon
dc.contributor.authorSmith, Alex
dc.contributor.authorRoman, Eve
dc.contributor.authorDiver, W. Ryan
dc.contributor.authorOffit, Kenneth
dc.contributor.authorZelenetz, Andrew
dc.contributor.authorKlein, Robert
dc.contributor.authorVillano, Danylo
dc.contributor.authorZheng, Tongzhang
dc.contributor.authorZhang, Yawei
dc.contributor.authorHolford, Theodore
dc.contributor.authorTurner, Jenny
dc.contributor.authorSouthey, Melissa
dc.contributor.authorClavel, Jacqueline
dc.contributor.authorVirtamo, Jarmo
dc.contributor.authorWeinstein, Stephanie
dc.contributor.authorRiboli, Elio
dc.contributor.authorVineis, Paolo
dc.contributor.authorKaaks, Rudolph
dc.contributor.authorBoeing, Heiner
dc.contributor.authorTjønneland, Anne
dc.contributor.authorAngelucci, Emanuele
dc.contributor.authorDi Lollo, Simonetta
dc.contributor.authorRais, Marco
dc.contributor.authorDe Vivo, Immaculata
dc.contributor.authorGiovannucci, Edward
dc.contributor.authorKraft, Peter
dc.contributor.authorHuang, Jinyan
dc.date.accessioned2019-09-23T15:33:06Z
dc.date.issued2016
dc.identifier.citationMachiela, Mitchell J., Qing Lan, Susan L. Slager, Roel C.H. Vermeulen, Lauren R. Teras, Nicola J. Camp, James R. Cerhan, et al. 2016. “Genetically Predicted Longer Telomere Length Is Associated with Increased Risk of B-Cell Lymphoma Subtypes.” Human Molecular Genetics 25 (8): 1663–76. https://doi.org/10.1093/hmg/ddw027.
dc.identifier.issn0964-6906
dc.identifier.issn1460-2083
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:41391940*
dc.description.abstractEvidence from a small number of studies suggests that longer telomere length measured in peripheral leukocytes is associated with an increased risk of non-Hodgkin lymphoma (NHL). However, these studies may be biased by reverse causation, confounded by unmeasured environmental exposures and might miss time points for which prospective telomere measurement would best reveal a relationship between telomere length and NHL risk. We performed an analysis of genetically inferred telomere length and NHL risk in a study of 10 102 NHL cases of the four most common B-cell histologic types and 9562 controls using a genetic risk score (GRS) comprising nine telomere length-associated single-nucleotide polymorphisms. This approach uses existing genotype data and estimates telomere length by weighing the number of telomere length-associated variant alleles an individual carries with the published change in kb of telomere length. The analysis of the telomere length GRS resulted in an association between longer telomere length and increased NHL risk [four B-cell histologic types combined; odds ratio (OR) = 1.49, 95% CI 1.22-1.82, P-value = 8.5 x 10(-5)]. Subtype-specific analyses indicated that chronic lymphocytic leukemia or small lymphocytic lymphoma (CLL/SLL) was the principal NHL subtype contributing to this association (OR = 2.60, 95% CI 1.93-3.51, P-value = 4.0 x 10(-10)). Significant interactions were observed across strata of sex for CLL/SLL and marginal zone lymphoma subtypes as well as age for the follicular lymphoma subtype. Our results indicate that a genetic background that favors longer telomere length may increase NHL risk, particularly risk of CLL/SLL, and are consistent with earlier studies relating longer telomere length with increased NHL risk.
dc.language.isoen_US
dc.publisherOxford University Press
dash.licenseMETA_ONLY
dc.titleGenetically predicted longer telomere length is associated with increased risk of B-cell lymphoma subtypes
dc.typeJournal Article
dc.description.versionVersion of Record
dc.relation.journalHuman Molecular Genetics
dash.depositing.authorGiovannucci, Edward L.::fd8dcb59a5a5859f2a85fabae12a60cf::600
dc.date.available2019-09-23T15:33:06Z
dash.workflow.comments1Science Serial ID 43809
dc.identifier.doi10.1093/hmg/ddw027
dash.source.volume25;8
dash.source.page1663


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