A meta-analysis of genome-wide association studies to identify prostate cancer susceptibility loci associated with aggressive and non-aggressive disease
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Olama, Ali Amin Al
Kote-Jarai, Zsofia
Schumacher, Fredrick
Wiklund, Fredrik
Berndt, Sonja
Benlloch, Sara
Giles, Graham
Severi, Gianluca
Neal, David
Hamdy, Freddie
Donovan, Jenny
Hunter, David
Henderson, Brian
Thun, Michael
Gaziano, Michael
Giovannucci, Edward
Siddiq, Afshan
Travis, Ruth
Cox, David
Canzian, Federico
Riboli, Elio
Key, Timothy
Andriole, Gerald
Albanes, Demetrius
Hayes, Richard
Schleutker, Johanna
Auvinen, Anssi
Tammela, Teuvo L. J.
Weischer, Maren
Stanford, Janet
Ostrander, Elaine
Cybulski, Cezary
Lubinski, Jan
Thibodeau, Stephen
Schaid, Daniel
Sorensen, Karina
Batra, Jyotsna
Clements, Judith
Chambers, Suzanne
Aitken, Joanne
Gardiner, Robert
Maier, Christiane
Vogel, Walther
Dörk, Thilo
Brenner, Hermann
Habuchi, Tomonori
Ingles, Sue
John, Esther
Dickinson, Joanne
Cannon-Albright, Lisa
Teixeira, Manuel
Kaneva, Radka
Zhang, Hong-Wei
Lu, Yong-Jie
Park, Jong
Cooney, Kathleen
Muir, Kenneth
Leongamornlert, Daniel
Saunders, Edward
Tymrakiewicz, Malgorzata
Mahmud, Nadiya
Guy, Michelle
Govindasami, Koveela
O'Brien, Lynne T.
Wilkinson, Rosemary
Hall, Amanda
Sawyer, Emma
Dadaev, Tokhir
Morrison, Jonathan
Dearnaley, David
Horwich, Alan
Huddart, Robert
Khoo, Vincent
Parker, Christopher
Van As, Nicholas
Woodhouse, Christopher
Thompson, Alan
Dudderidge, Tim
Ogden, Chris
Cooper, Colin
Lophatonanon, Artitaya
Southey, Melissa
Hopper, John
English, Dallas
Virtamo, Jarmo
Le Marchand, Loic
Campa, Daniele
Kaaks, Rudolf
Lindstrom, Sara
Diver, W. Ryan
Gapstur, Susan
Yeager, Meredith
Cox, Angela
Stern, Mariana
Corral, Roman
Aly, Markus
Isaacs, William
Adolfsson, Jan
Xu, Jianfeng
Zheng, S. Lilly
Published Version
https://doi.org/10.1093/hmg/dds425Metadata
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Amin Al Olama, A., Z. Kote-Jarai, F. R. Schumacher, F. Wiklund, S. I. Berndt, S. Benlloch, G. G. Giles, et al. 2012. “A Meta-Analysis of Genome-Wide Association Studies to Identify Prostate Cancer Susceptibility Loci Associated with Aggressive and Non-Aggressive Disease.” Human Molecular Genetics 22 (2): 408–15. https://doi.org/10.1093/hmg/dds425.Abstract
Genome-wide association studies (GWAS) have identified multiple common genetic variants associated with an increased risk of prostate cancer (PrCa), but these explain less than one-third of the heritability. To identify further susceptibility alleles, we conducted a meta-analysis of four GWAS including 5953 cases of aggressive PrCa and 11 463 controls (men without PrCa). We computed association tests for approximately 2.6 million SNPs and followed up the most significant SNPs by genotyping 49 121 samples in 29 studies through the international PRACTICAL and BPC3 consortia. We not only confirmed the association of a PrCa susceptibility locus, rs11672691 on chromosome 19, but also showed an association with aggressive PrCa [odds ratio 1.12 (95 confidence interval 1.031.21), P 1.4 10(8)]. This report describes a genetic variant which is associated with aggressive PrCa, which is a type of PrCa associated with a poorer prognosis.Citable link to this page
http://nrs.harvard.edu/urn-3:HUL.InstRepos:41391946
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