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dc.contributor.authorOlama, Ali Amin Al
dc.contributor.authorKote-Jarai, Zsofia
dc.contributor.authorSchumacher, Fredrick
dc.contributor.authorWiklund, Fredrik
dc.contributor.authorBerndt, Sonja
dc.contributor.authorBenlloch, Sara
dc.contributor.authorGiles, Graham
dc.contributor.authorSeveri, Gianluca
dc.contributor.authorNeal, David
dc.contributor.authorHamdy, Freddie
dc.contributor.authorDonovan, Jenny
dc.contributor.authorHunter, David
dc.contributor.authorHenderson, Brian
dc.contributor.authorThun, Michael
dc.contributor.authorGaziano, Michael
dc.contributor.authorGiovannucci, Edward
dc.contributor.authorSiddiq, Afshan
dc.contributor.authorTravis, Ruth
dc.contributor.authorCox, David
dc.contributor.authorCanzian, Federico
dc.contributor.authorRiboli, Elio
dc.contributor.authorKey, Timothy
dc.contributor.authorAndriole, Gerald
dc.contributor.authorAlbanes, Demetrius
dc.contributor.authorHayes, Richard
dc.contributor.authorSchleutker, Johanna
dc.contributor.authorAuvinen, Anssi
dc.contributor.authorTammela, Teuvo L. J.
dc.contributor.authorWeischer, Maren
dc.contributor.authorStanford, Janet
dc.contributor.authorOstrander, Elaine
dc.contributor.authorCybulski, Cezary
dc.contributor.authorLubinski, Jan
dc.contributor.authorThibodeau, Stephen
dc.contributor.authorSchaid, Daniel
dc.contributor.authorSorensen, Karina
dc.contributor.authorBatra, Jyotsna
dc.contributor.authorClements, Judith
dc.contributor.authorChambers, Suzanne
dc.contributor.authorAitken, Joanne
dc.contributor.authorGardiner, Robert
dc.contributor.authorMaier, Christiane
dc.contributor.authorVogel, Walther
dc.contributor.authorDörk, Thilo
dc.contributor.authorBrenner, Hermann
dc.contributor.authorHabuchi, Tomonori
dc.contributor.authorIngles, Sue
dc.contributor.authorJohn, Esther
dc.contributor.authorDickinson, Joanne
dc.contributor.authorCannon-Albright, Lisa
dc.contributor.authorTeixeira, Manuel
dc.contributor.authorKaneva, Radka
dc.contributor.authorZhang, Hong-Wei
dc.contributor.authorLu, Yong-Jie
dc.contributor.authorPark, Jong
dc.contributor.authorCooney, Kathleen
dc.contributor.authorMuir, Kenneth
dc.contributor.authorLeongamornlert, Daniel
dc.contributor.authorSaunders, Edward
dc.contributor.authorTymrakiewicz, Malgorzata
dc.contributor.authorMahmud, Nadiya
dc.contributor.authorGuy, Michelle
dc.contributor.authorGovindasami, Koveela
dc.contributor.authorO'Brien, Lynne T.
dc.contributor.authorWilkinson, Rosemary
dc.contributor.authorHall, Amanda
dc.contributor.authorSawyer, Emma
dc.contributor.authorDadaev, Tokhir
dc.contributor.authorMorrison, Jonathan
dc.contributor.authorDearnaley, David
dc.contributor.authorHorwich, Alan
dc.contributor.authorHuddart, Robert
dc.contributor.authorKhoo, Vincent
dc.contributor.authorParker, Christopher
dc.contributor.authorVan As, Nicholas
dc.contributor.authorWoodhouse, Christopher
dc.contributor.authorThompson, Alan
dc.contributor.authorDudderidge, Tim
dc.contributor.authorOgden, Chris
dc.contributor.authorCooper, Colin
dc.contributor.authorLophatonanon, Artitaya
dc.contributor.authorSouthey, Melissa
dc.contributor.authorHopper, John
dc.contributor.authorEnglish, Dallas
dc.contributor.authorVirtamo, Jarmo
dc.contributor.authorLe Marchand, Loic
dc.contributor.authorCampa, Daniele
dc.contributor.authorKaaks, Rudolf
dc.contributor.authorLindstrom, Sara
dc.contributor.authorDiver, W. Ryan
dc.contributor.authorGapstur, Susan
dc.contributor.authorYeager, Meredith
dc.contributor.authorCox, Angela
dc.contributor.authorStern, Mariana
dc.contributor.authorCorral, Roman
dc.contributor.authorAly, Markus
dc.contributor.authorIsaacs, William
dc.contributor.authorAdolfsson, Jan
dc.contributor.authorXu, Jianfeng
dc.contributor.authorZheng, S. Lilly
dc.date.accessioned2019-09-23T15:33:09Z
dc.date.issued2013
dc.identifier.citationAmin Al Olama, A., Z. Kote-Jarai, F. R. Schumacher, F. Wiklund, S. I. Berndt, S. Benlloch, G. G. Giles, et al. 2012. “A Meta-Analysis of Genome-Wide Association Studies to Identify Prostate Cancer Susceptibility Loci Associated with Aggressive and Non-Aggressive Disease.” Human Molecular Genetics 22 (2): 408–15. https://doi.org/10.1093/hmg/dds425.
dc.identifier.issn0964-6906
dc.identifier.issn1460-2083
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:41391946*
dc.description.abstractGenome-wide association studies (GWAS) have identified multiple common genetic variants associated with an increased risk of prostate cancer (PrCa), but these explain less than one-third of the heritability. To identify further susceptibility alleles, we conducted a meta-analysis of four GWAS including 5953 cases of aggressive PrCa and 11 463 controls (men without PrCa). We computed association tests for approximately 2.6 million SNPs and followed up the most significant SNPs by genotyping 49 121 samples in 29 studies through the international PRACTICAL and BPC3 consortia. We not only confirmed the association of a PrCa susceptibility locus, rs11672691 on chromosome 19, but also showed an association with aggressive PrCa [odds ratio 1.12 (95 confidence interval 1.031.21), P 1.4 10(8)]. This report describes a genetic variant which is associated with aggressive PrCa, which is a type of PrCa associated with a poorer prognosis.
dc.language.isoen_US
dc.publisherOxford University Press
dash.licenseMETA_ONLY
dc.titleA meta-analysis of genome-wide association studies to identify prostate cancer susceptibility loci associated with aggressive and non-aggressive disease
dc.typeJournal Article
dc.description.versionVersion of Record
dc.relation.journalHuman Molecular Genetics
dash.depositing.authorGiovannucci, Edward L.::fd8dcb59a5a5859f2a85fabae12a60cf::600
dc.date.available2019-09-23T15:33:09Z
dash.workflow.comments1Science Serial ID 43978
dc.identifier.doi10.1093/hmg/dds425
dash.source.volume22;2
dash.source.page408


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