Show simple item record

dc.contributor.authorSchernhammer, E. S.
dc.contributor.authorKang, J.-H.
dc.contributor.authorChan, A. T.
dc.contributor.authorMichaud, D. S.
dc.contributor.authorSkinner, H. G.
dc.contributor.authorGiovannucci, E.
dc.contributor.authorColditz, G. A.
dc.contributor.authorFuchs, C. S.
dc.date.accessioned2019-09-23T15:33:15Z
dc.date.issued2004
dc.identifier.citationSchernhammer, E. S., J.-H. Kang, A. T. Chan, D. S. Michaud, H. G. Skinner, E. Giovannucci, G. A. Colditz, and C. S. Fuchs. 2004. “A Prospective Study of Aspirin Use and the Risk of Pancreatic Cancer in Women.” JNCI Journal of the National Cancer Institute 96 (1): 22–28. https://doi.org/10.1093/jnci/djh001.
dc.identifier.issn0027-8874
dc.identifier.issn0198-0157
dc.identifier.issn1460-2105
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:41391960*
dc.description.abstractBackground: In vitro experiments and limited animal studies suggest that aspirin and nonsteroidal anti-inflammatory drugs may inhibit pancreatic carcinogenesis. Because few studies have examined the association between aspirin use and pancreatic cancer in humans and the results have been inconsistent, we examined the relationship between aspirin use and the development of pancreatic cancer in the Nurses' Health Study. Methods: Among 88 378 women without cancer at baseline, we documented 161 cases of pancreatic cancer during 18 years of follow-up. Aspirin use was first assessed at baseline in 1980 and updated biennially thereafter. All statistical tests were two-sided. Results: Participants were classified according to history of aspirin use. In a multivariable analysis, the risk of pancreatic cancer was not associated with current regular aspirin use (defined as two or more standard tablets per week; relative risk [RR] = 1.20, 95% confidence interval [CI] = 0.87 to 1.65), compared with use of fewer than two tablets per week. Increasing duration of regular aspirin use, compared with non-use, was associated with a statistically significant increase in risk: Women who reported more than 20 years of regular aspirin use had an increased risk of pancreatic cancer (RR = 1.58, 95% CI = 1.03 to 2.43; P-trend = .01). Among women who reported aspirin use on at least two of three consecutive biennial questionnaires compared with consistent non-users of aspirin, the risk increased with dose (one to three tablets per week: RR = 1.11, 95% CI = 0.70 to 1.76; four to six tablets per week: RR = 1.29, 95% CI = 0.70 to 2.40; seven to 13 tablets per week: RR = 1.41, 95% CI = 0.76 to 2.61; and 2:14 tablets per week: RR = 1.86, 95% CI = 1.03 to 3.35) (P-trend = .02). Conclusion: Extended periods of regular aspirin use appear to be associated with a statistically significantly increased risk of pancreatic cancer among women.
dc.language.isoen_US
dc.publisherOxford University Press
dash.licenseMETA_ONLY
dc.titleA Prospective Study of Aspirin Use and the Risk of Pancreatic Cancer in Women
dc.typeJournal Article
dc.description.versionVersion of Record
dc.relation.journalJournal of the National Cancer Institute
dash.depositing.authorGiovannucci, Edward L.::fd8dcb59a5a5859f2a85fabae12a60cf::600
dc.date.available2019-09-23T15:33:15Z
dash.workflow.comments1Science Serial ID 57216
dc.identifier.doi10.1093/jnci/djh001
dash.source.volume96;1
dash.source.page22-28


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record