A Prospective Study of Plasma Selenium Levels and Prostate Cancer Risk
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Giovannucci, E. L.
Morris, J. S.
Willett, Walter C.::94559ea206eef8a8844fc5b80654fa5b::600
Gaziano, J. M.
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CitationLi, H., M. J. Stampfer, E. L. Giovannucci, J. S. Morris, W. C. Willett, J. M. Gaziano, and J. Ma. 2004. “A Prospective Study of Plasma Selenium Levels and Prostate Cancer Risk.” JNCI Journal of the National Cancer Institute 96 (9): 696–703. https://doi.org/10.1093/jnci/djh125.
AbstractBackground: Epidemiologic studies suggest that low selenium levels are associated with an increased incidence of prostate cancer, although results are conflicting. We examined the association between pre-diagnostic plasma selenium levels and risk of prostate cancer in men enrolled in the Physicians' Health Study. Methods: Using plasma samples obtained in 1982 from healthy men enrolled in the study, we conducted a nested case-control study among 586 men diagnosed with prostate cancer during 13 years of follow-up and 577 control subjects. Odds ratios (ORs) and 95% confidence intervals (CIs) for the risk of prostate cancer in pre-(before October 1990) and post- (after October 1990) prostate-specific antigen (PSA) screening eras were calculated using multivariable logistic regression. Results: Prediagnostic plasma selenium levels were inversely associated with risk of advanced prostate cancer (5(th) versus 1(st) quintile OR=0.52, 95% CI=0.28 to 0.98; P-trend=.05), even among men diagnosed after 1990 (5(th) versus 1(st) quintile OR=0.39, 95% CI=0.16 to 0.97). The inverse association with prostate cancer risk was observed only for case subjects with elevated baseline PSA levels (PSA >4 ng/mL, 5(th) versus 1(st) quintile OR=0.49, 95% CI=0.28 to 0.86; P-trend=.002). These inverse associations were observed in both pre- and post-PSA eras. Conclusions: The inverse association between baseline plasma selenium levels and risk of advanced prostate cancer, even among men diagnosed during the post-PSA era, suggests that higher levels of selenium may slow prostate cancer tumor progression. Ongoing randomized trials of selenium supplements may help to further evaluate this issue.
Citable link to this pagehttp://nrs.harvard.edu/urn-3:HUL.InstRepos:41391962
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