Alcohol intake and pancreatic cancer: a pooled analysis from the pancreatic cancer cohort consortium (PanScan)
View/ Open
Author
Michaud, Dominique S.
Vrieling, Alina
Jiao, Li
Mendelsohn, Julie B.
Steplowski, Emily
Lynch, Shannon M.
Wactawski-Wende, Jean
Arslan, Alan A.
Bueno-de-Mesquita, H. Bas
Fuchs, Charles S.
Gross, Myron
Helzlsouer, Kathy
Jacobs, Eric J.
LaCroix, Andrea
Petersen, Gloria
Zheng, Wei
Allen, Naomi
Ammundadottir, Laufey
Bergmann, Manuela M.
Boffetta, Paolo
Buring, Julie E.
Canzian, Federico
Chanock, Stephen J.
Clavel-Chapelon, Françoise
Clipp, Sandra
Freiberg, Matthew S.
Gaziano, J. Michael
Giovannucci, Edward L.
Hankinson, Susan
Hartge, Patricia
Hoover, Robert N.
Hubbell, F. Allan
Hunter, David J.
Hutchinson, Amy
Jacobs, Kevin
Kooperberg, Charles
Kraft, Peter
Manjer, Jonas
Navarro, Carmen
Peeters, Petra M.
Shu, Xiao-Ou
Stevens, Victoria
Thomas, Gilles
Tjønneland, Anne
Tobias, Geoffrey S.
Trichopoulos, Dimitrios
Tumino, Rosario
Vineis, Paolo
Virtamo, Jarmo
Wallace, Robert
Wolpin, Brian M.
Yu, Kai
Zeleniuch-Jacquotte, Anne
Stolzenberg-Solomon, Rachael Z.
Published Version
https://doi.org/10.1007/s10552-010-9548-zMetadata
Show full item recordCitation
Michaud, Dominique S., Alina Vrieling, Li Jiao, Julie B. Mendelsohn, Emily Steplowski, Shannon M. Lynch, Jean Wactawski-Wende, et al. 2010. “Alcohol Intake and Pancreatic Cancer: A Pooled Analysis from the Pancreatic Cancer Cohort Consortium (PanScan).” Cancer Causes & Control 21 (8): 1213–25. https://doi.org/10.1007/s10552-010-9548-z.Abstract
The literature has consistently reported no association between low to moderate alcohol consumption and pancreatic cancer; however, a few studies have shown that high levels of intake may increase risk. Most single studies have limited power to detect associations even in the highest alcohol intake categories or to examine associations by alcohol type. We analyzed these associations using 1,530 pancreatic cancer cases and 1,530 controls from the Pancreatic Cancer Cohort Consortium (PanScan) nested case-control study. Odds ratios (OR) and 95% confidence intervals (95% CI) were calculated using unconditional logistic regression, adjusting for potential confounders. We observed no significant overall association between total alcohol (ethanol) intake and pancreatic cancer risk (OR = 1.38, 95% CI = 0.86-2.23, for 60 or more g/day vs. > 0 to < 5 g/day). A statistically significant increase in risk was observed among men consuming 45 or more grams of alcohol from liquor per day (OR = 2.23, 95% CI = 1.02-4.87, compared to 0 g/day of alcohol from liquor, P-trend = 0.12), but not among women (OR = 1.35, 95% CI = 0.63-2.87, for 30 or more g/day of alcohol from liquor, compared to none). No associations were noted for wine or beer intake. Overall, no significant increase in risk was observed, but a small effect among heavy drinkers cannot be ruled out.Terms of Use
This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAACitable link to this page
http://nrs.harvard.edu/urn-3:HUL.InstRepos:41392072
Collections
- SPH Scholarly Articles [6311]
Contact administrator regarding this item (to report mistakes or request changes)