Show simple item record

dc.contributor.authorGiovannucci, Edward
dc.contributor.authorStampfer, Meir
dc.contributor.authorKrithivas, Krishna
dc.contributor.authorBrown, Myles
dc.contributor.authorBrufsky, Adam
dc.contributor.authorTalcott, James
dc.contributor.authorHennekens, Charles
dc.contributor.authorKantoff, Philip
dc.date.accessioned2019-09-23T15:34:35Z
dc.date.issued1997
dc.identifier.citationGiovannucci, E., M. J. Stampfer, K. Krithivas, M. Brown, A. Brufsky, J. Talcott, C. H. Hennekens, and P. W. Kantoff. 1997. “The CAG Repeat within the Androgen Receptor Gene and Its Relationship to Prostate Cancer.” Proceedings of the National Academy of Sciences 94 (7): 3320–23. https://doi.org/10.1073/pnas.94.7.3320.
dc.identifier.issn0027-8424
dc.identifier.issn0744-2831
dc.identifier.issn1091-6490
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:41392102*
dc.description.abstractThe length of a polymorphic CAG repeat sequence, occurring in the androgen receptor gene, is inversely correlated with transcriptional activity by the andro gen receptor, Because heightened androgenic stimulation may Increase risk of prostate cancer development and progression, we examined whether shorter CAG repeats in the androgen receptor gene are related to higher risk of prostate cancel. We conducted a nested case-control study of 587 newly diagnosed cases of prostate cancer detected between 1982 and 1995, and 588 controls without prostate cancer, within the Physician's Health Study, An association existed between fewer androgen receptor gene CAG repeats and higher risk of total prostate [relative risk (RR) = 1.52; 95% confidence interval 0.92-2.49; P trend = 0.04; for men with CAG repeat lengths less than or equal to 18 relative to greater than or equal to 26 repeats], In particular, a shorter CAG repeat sequence was associated with cancers characterized hy extraprostatic extension or distant metastases (stage C or D) or high histologic grade (RR = 2.14; CI = 1.14-4.01; P trend = 0.001), This association was observed individually both for high stage (RR = 2.23) and high grade prostate cancer (RR = 1,89), Men with shorter repeats were at particularly high risk for distant metastatic and fatal prostate cancer, Variability in the CAG repeat length was not associated with low grade or low stage disease, These results demonstrate that a shorter CAG repeat sequence in the androgen receptor gene predicts higher grade and advanced stage of prostate cancer at diagnosis, and metastasis and mortality from the disease, The clinical implications of these results should be evaluated further.
dc.language.isoen_US
dc.publisherNational Academy of Sciences
dash.licenseLAA
dc.titleThe CAG repeat within the androgen receptor gene and its relationship to prostate cancer
dc.typeJournal Article
dc.description.versionVersion of Record
dc.relation.journalProceedings of the National Academy of Sciences of the United States of America
dash.depositing.authorGiovannucci, Edward L.::fd8dcb59a5a5859f2a85fabae12a60cf::600
dc.date.available2019-09-23T15:34:35Z
dash.workflow.comments1Science Serial ID 88861
dc.identifier.doi10.1073/pnas.94.7.3320
dash.source.volume94;7
dash.source.page3320
dash.contributor.affiliatedStampfer, Meir


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record