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dc.contributor.authorTworoger, Shelley S.
dc.contributor.authorHecht, Jonathan L.
dc.contributor.authorGiovannucci, Edward
dc.contributor.authorHankinson, Susan E.
dc.date.accessioned2019-09-23T15:34:46Z
dc.date.issued2006
dc.identifier.citationTworoger, Shelley S., Jonathan L. Hecht, Edward Giovannucci, and Susan E. Hankinson. 2006. “Intake of Folate and Related Nutrients in Relation to Risk of Epithelial Ovarian Cancer.” American Journal of Epidemiology 163 (12): 1101–11. https://doi.org/10.1093/aje/kwj128.
dc.identifier.issn0002-9262
dc.identifier.issn1476-6256
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:41392122*
dc.description.abstractAssessments of the relation between folate intake and ovarian cancer risk have been limited and inconsistent. Therefore, the authors prospectively examined the association of dietary and supplemental intakes of folate, methionine, and vitamin B-6 with ovarian cancer risk among 80,254 Nurses' Health Study participants. Beginning in 1976, women completed biennial questionnaires assessing ovarian cancer risk factors; starting in 1980, food frequency questionnaires were administered every 2-4 years. During 22 years of follow-up (1980-2002), the authors confirmed 481 incident epithelial ovarian cancers. There were no associations between total folate (top quintile vs. bottom: relative risk (RR) = 1.21, 95% confidence interval (Cl): 0.92,1.60), methionine (RR = 1.00, 95% Cl: 0.76, 1.33), dietary vitamin B-6 (RR = 1.09, 95% Cl: 0.81, 1.47), or total vitamin B-6 (RR = 1.13, 95% Cl: 0.85, 1.51) intake and ovarian cancer risk. Higher dietary folate was associated with a modestly decreased risk after exclusion of cases diagnosed during the 4 follow-up years after dietary assessment (RR = 0.66, 95% Cl: 0.43, 1.03) and for the serous subtype (RR = 0.51, 95% Cl: 0.31, 0.84). Results did not vary by alcohol intake, multivitamin use, menopausal status, or oral contraceptive use. There was little evidence that folate, methionine, and vitamin B6 are important in ovarian cancer risk, although dietary folate was inversely associated with risk in some analyses.
dc.language.isoen_US
dc.publisherOxford University Press
dash.licenseMETA_ONLY
dc.titleIntake of Folate and Related Nutrients in Relation to Risk of Epithelial Ovarian Cancer
dc.typeJournal Article
dc.description.versionVersion of Record
dc.relation.journalAmerican Journal of Epidemiology
dash.depositing.authorGiovannucci, Edward L.::fd8dcb59a5a5859f2a85fabae12a60cf::600
dc.date.available2019-09-23T15:34:46Z
dash.workflow.comments1Science Serial ID 2090
dc.identifier.doi10.1093/aje/kwj128
dash.source.volume163;12
dash.source.page1101-1111


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