Genome-wide association study identifies multiple loci associated with bladder cancer risk
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Figueroa, Jonine D.
Ye, Yuanqing
Siddiq, Afshan
Garcia-Closas, Montserrat
Chatterjee, Nilanjan
Prokunina-Olsson, Ludmila
Cortessis, Victoria K.
Kooperberg, Charles
Cussenot, Olivier
Benhamou, Simone
Prescott, Jennifer
Porru, Stefano
Dinney, Colin P.
Malats, Núria
Baris, Dalsu
Purdue, Mark
Jacobs, Eric J.
Albanes, Demetrius
Wang, Zhaoming
Deng, Xiang
Chung, Charles C.
Tang, Wei
Bueno-de-Mesquita, H. Bas
Trichopoulos, Dimitrios
Ljungberg, Börje
Clavel-Chapelon, Françoise
Weiderpass, Elisabete
Krogh, Vittorio
Dorronsoro, Miren
Travis, Ruth
Tjønneland, Anne
Brenan, Paul
Chang-Claude, Jenny
Riboli, Elio
Conti, David
Gago-Dominguez, Manuela
Stern, Mariana C.
Pike, Malcolm C.
Berg, David Den
Yuan, Jian-Min
Hohensee, Chancellor
Rodabough, Rebecca
Cancel-Tassin, Geraldine
Roupret, Morgan
Comperat, Eva
Chen, Constance
Vivo, Immaculata De
Giovannucci, Edward
Hunter, David J.
Kraft, Peter
Lindstrom, Sara
Carta, Angela
Pavanello, Sofia
Arici, Cecilia
Mastrangelo, Giuseppe
Kamat, Ashish M.
Lerner, Seth P.
Grossman, H. Barton
Lin, Jie
Gu, Jian
Pu, Xia
Hutchinson, Amy
Burdette, Laurie
Wheeler, William
Kogevinas, Manolis
Tardón, Adonina
Serra, Consol
Carrato, Alfredo
García-Closas, Reina
Lloreta, Josep
Schwenn, Molly
Karagas, Margaret R.
Johnson, Alison
Schned, Alan
Armenti, Karla R.
Hosain, G. M.
Andriole, Gerald, Jr.
Grubb, Robert III
Black, Amanda
Diver, W. Ryan
Gapstur, Susan M.
Weinstein, Stephanie J.
Virtamo, Jarmo
Haiman, Chris A.
Landi, Maria T.
Caporaso, Neil
Fraumeni, Joseph F. Jr.
Vineis, Paolo
Wu, Xifeng
Silverman, Debra T.
Chanock, Stephen
Rothman, Nathaniel
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https://doi.org/10.1093/hmg/ddt519Metadata
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Figueroa, Jonine D., Yuanqing Ye, Afshan Siddiq, Montserrat Garcia-Closas, Nilanjan Chatterjee, Ludmila Prokunina-Olsson, Victoria K. Cortessis, et al. 2013. “Genome-Wide Association Study Identifies Multiple Loci Associated with Bladder Cancer Risk.” Human Molecular Genetics 23 (5): 1387–98. https://doi.org/10.1093/hmg/ddt519.Abstract
Candidate gene and genome-wide association studies (GWAS) have identified 11 independent susceptibility loci associated with bladder cancer risk. To discover additional risk variants, we conducted a new GWAS of 2422 bladder cancer cases and 5751 controls, followed by a meta-analysis with two independently published bladder cancer GWAS, resulting in a combined analysis of 6911 cases and 11 814 controls of European descent. TaqMan genotyping of 13 promising single nucleotide polymorphisms with P < 1 x 10(-5) was pursued in a follow-up set of 801 cases and 1307 controls. Two new loci achieved genome-wide statistical significance: rs10936599 on 3q26.2 (P = 4.53 x 10(-9)) and rs907611 on 11p15.5 (P = 4.11 x 10(-8)). Two notable loci were also identified that approached genome-wide statistical significance: rs6104690 on 20p12.2 (P = 7.13 x 10(-7)) and rs4510656 on 6p22.3 (P = 6.98 x 10(-7)); these require further studies for confirmation. In conclusion, our study has identified new susceptibility alleles for bladder cancer risk that require fine-mapping and laboratory investigation, which could further understanding into the biological underpinnings of bladder carcinogenesis.Citable link to this page
http://nrs.harvard.edu/urn-3:HUL.InstRepos:41392191
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