Thymic Selection of T-Cell Receptors as an Extreme Value Problem
Chakraborty, Arup K.
Shakhnovich, Eugene I.
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CitationKošmrlj, Andrej, Arup K. Chakraborty, Mehran Kardar, and Eugene I. Shakhnovich. 2009. “Thymic Selection of T-Cell Receptors as an Extreme Value Problem.” Physical Review Letters 103 (6). https://doi.org/10.1103/physrevlett.103.068103.
AbstractT lymphocytes (T cells) orchestrate adaptive immune responses upon activation. T-cell activation requires sufficiently strong binding of T-cell receptors on their surface to short peptides (p) derived from foreign proteins, which are bound to major histocompatibility gene products (displayed on antigen-presenting cells). A diverse and self-tolerant T-cell repertoire is selected in the thymus. We map thymic selection processes to an extreme value problem and provide an analytic expression for the amino acid compositions of selected T-cell receptors (which enable its recognition functions).
Citable link to this pagehttp://nrs.harvard.edu/urn-3:HUL.InstRepos:41417320
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