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dc.contributor.authorAmes, Bruce
dc.contributor.authorGold, Lois
dc.contributor.authorWillett, Walter C.::94559ea206eef8a8844fc5b80654fa5b::600
dc.date.accessioned2019-09-30T11:55:38Z
dc.date.issued1995
dc.identifier.citationAmes, B. N., L. S. Gold, and W. C. Willett. 1995. “The Causes and Prevention of Cancer.” Proceedings of the National Academy of Sciences 92 (12): 5258–65. https://doi.org/10.1073/pnas.92.12.5258.
dc.identifier.issn0027-8424
dc.identifier.issn0744-2831
dc.identifier.issn1091-6490
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:41426747*
dc.description.abstractEpidemiological evidence indicates that avoidance of smoking, increased consumption of fruits and vegetables, and control of infections will have a major effect on reducing rates of cancer, Other factors include avoidance of intense sun exposure, increases in physical activity, and reduction of alcohol consumption and possibly red meat, A substantial reduction in breast cancer is likely to require modification of ses hormone levels, and development of practical methods for doing so is a high research priority, Resolution of the potential protective roles of specific antioxidants and other constituents of fruits and vegetables deserves major attention, Mechanistic studies of carcinogenesis indicate an important role of endogenous oxidative damage to DNA that is balanced by elaborate defense and repair processes, Also key is the rate of cell division, which is influenced by hormones, growth, cytotoxicity, and inflammation, as this determines the probability of converting DNA lesions to mutations, These mechanisms may underlie many epidemiologic observations.
dc.language.isoen_US
dc.publisherNational Academy of Sciences
dash.licenseLAA
dc.titleThe causes and prevention of cancer
dc.typeJournal Article
dc.description.versionVersion of Record
dc.relation.journalProceedings of the National Academy of Sciences of the United States of America
dash.depositing.authorWillett, Walter C.::94559ea206eef8a8844fc5b80654fa5b::600
dc.date.available2019-09-30T11:55:38Z
dash.workflow.comments1Science Serial ID 80008
dc.identifier.doi10.1073/pnas.92.12.5258
dash.source.volume92;12
dash.source.page5258-5265


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