Association of eGFR-Related Loci Identified by GWAS with Incident CKD and ESRD
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Author
Böger, Carsten A.
Gorski, Mathias
Li, Man
Hoffmann, Michael M.
Huang, Chunmei
Yang, Qiong
Teumer, Alexander
Krane, Vera
O'Seaghdha, Conall M.
Kutalik, Zoltán
Wichmann, H.-Erich
Haak, Thomas
Boes, Eva
Coassin, Stefan
Coresh, Josef
Kollerits, Barbara
Haun, Margot
Paulweber, Bernhard
Köttgen, Anna
Li, Guo
Shlipak, Michael G.
Powe, Neil
Hwang, Shih-Jen
Dehghan, Abbas
Rivadeneira, Fernando
Uitterlinden, André
Hofman, Albert
Beckmann, Jacques S.
Krämer, Bernhard K.
Witteman, Jacqueline
Bochud, Murielle
Siscovick, David
Rettig, Rainer
Kronenberg, Florian
Wanner, Christoph
Thadhani, Ravi I.
Heid, Iris M.
Fox, Caroline S.
Kao, W. H.
Kim, Stuart K.
Published Version
https://doi.org/10.1371/journal.pgen.1002292Metadata
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Böger, Carsten A., Mathias Gorski, Man Li, Michael M. Hoffmann, Chunmei Huang, Qiong Yang, Alexander Teumer, et al. 2011. “Association of eGFR-Related Loci Identified by GWAS with Incident CKD and ESRD.” Edited by Stuart K. Kim. PLoS Genetics 7 (9): e1002292. https://doi.org/10.1371/journal.pgen.1002292.Abstract
Family studies suggest a genetic component to the etiology of chronic kidney disease (CKD) and end stage renal disease (ESRD). Previously, we identified 16 loci for eGFR in genome-wide association studies, but the associations of these single nucleotide polymorphisms (SNPs) for incident CKD or ESRD are unknown. We thus investigated the association of these loci with incident CKD in 26,308 individuals of European ancestry free of CKD at baseline drawn from eight population-based cohorts followed for a median of 7.2 years (including 2,122 incident CKD cases defined as eGFR < 60ml/min/1.73m(2) at follow-up) and with ESRD in four case-control studies in subjects of European ancestry (3,775 cases, 4,577 controls). SNPs at 11 of the 16 loci (UMOD, PRKAG2, ANXA9, DAB2, SHROOM3, DACH1, STC1, SLC34A1, ALMS1/NAT8, UBE2Q2, and GCKR) were associated with incident CKD; p-values ranged from p = 4.1e-9 in UMOD to p = 0.03 in GCKR. After adjusting for baseline eGFR, six of these loci remained significantly associated with incident CKD (UMOD, PRKAG2, ANXA9, DAB2, DACH1, and STC1). SNPs in UMOD (OR = 0.92, p = 0.04) and GCKR (OR = 0.93, p = 0.03) were nominally associated with ESRD. In summary, the majority of eGFR-related loci are either associated or show a strong trend towards association with incident CKD, but have modest associations with ESRD in individuals of European descent. Additional work is required to characterize the association of genetic determinants of CKD and ESRD at different stages of disease progression.Terms of Use
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