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dc.contributor.authorBöger, Carsten A.
dc.contributor.authorGorski, Mathias
dc.contributor.authorLi, Man
dc.contributor.authorHoffmann, Michael M.
dc.contributor.authorHuang, Chunmei
dc.contributor.authorYang, Qiong
dc.contributor.authorTeumer, Alexander
dc.contributor.authorKrane, Vera
dc.contributor.authorO'Seaghdha, Conall M.
dc.contributor.authorKutalik, Zoltán
dc.contributor.authorWichmann, H.-Erich
dc.contributor.authorHaak, Thomas
dc.contributor.authorBoes, Eva
dc.contributor.authorCoassin, Stefan
dc.contributor.authorCoresh, Josef
dc.contributor.authorKollerits, Barbara
dc.contributor.authorHaun, Margot
dc.contributor.authorPaulweber, Bernhard
dc.contributor.authorKöttgen, Anna
dc.contributor.authorLi, Guo
dc.contributor.authorShlipak, Michael G.
dc.contributor.authorPowe, Neil
dc.contributor.authorHwang, Shih-Jen
dc.contributor.authorDehghan, Abbas
dc.contributor.authorRivadeneira, Fernando
dc.contributor.authorUitterlinden, André
dc.contributor.authorHofman, Albert
dc.contributor.authorBeckmann, Jacques S.
dc.contributor.authorKrämer, Bernhard K.
dc.contributor.authorWitteman, Jacqueline
dc.contributor.authorBochud, Murielle
dc.contributor.authorSiscovick, David
dc.contributor.authorRettig, Rainer
dc.contributor.authorKronenberg, Florian
dc.contributor.authorWanner, Christoph
dc.contributor.authorThadhani, Ravi I.
dc.contributor.authorHeid, Iris M.
dc.contributor.authorFox, Caroline S.
dc.contributor.authorKao, W. H.
dc.contributor.authorKim, Stuart K.
dc.date.accessioned2019-09-30T11:55:39Z
dc.date.issued2011
dc.identifier.citationBöger, Carsten A., Mathias Gorski, Man Li, Michael M. Hoffmann, Chunmei Huang, Qiong Yang, Alexander Teumer, et al. 2011. “Association of eGFR-Related Loci Identified by GWAS with Incident CKD and ESRD.” Edited by Stuart K. Kim. PLoS Genetics 7 (9): e1002292. https://doi.org/10.1371/journal.pgen.1002292.
dc.identifier.issn1553-7390
dc.identifier.issn1553-7404
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:41426748*
dc.description.abstractFamily studies suggest a genetic component to the etiology of chronic kidney disease (CKD) and end stage renal disease (ESRD). Previously, we identified 16 loci for eGFR in genome-wide association studies, but the associations of these single nucleotide polymorphisms (SNPs) for incident CKD or ESRD are unknown. We thus investigated the association of these loci with incident CKD in 26,308 individuals of European ancestry free of CKD at baseline drawn from eight population-based cohorts followed for a median of 7.2 years (including 2,122 incident CKD cases defined as eGFR < 60ml/min/1.73m(2) at follow-up) and with ESRD in four case-control studies in subjects of European ancestry (3,775 cases, 4,577 controls). SNPs at 11 of the 16 loci (UMOD, PRKAG2, ANXA9, DAB2, SHROOM3, DACH1, STC1, SLC34A1, ALMS1/NAT8, UBE2Q2, and GCKR) were associated with incident CKD; p-values ranged from p = 4.1e-9 in UMOD to p = 0.03 in GCKR. After adjusting for baseline eGFR, six of these loci remained significantly associated with incident CKD (UMOD, PRKAG2, ANXA9, DAB2, DACH1, and STC1). SNPs in UMOD (OR = 0.92, p = 0.04) and GCKR (OR = 0.93, p = 0.03) were nominally associated with ESRD. In summary, the majority of eGFR-related loci are either associated or show a strong trend towards association with incident CKD, but have modest associations with ESRD in individuals of European descent. Additional work is required to characterize the association of genetic determinants of CKD and ESRD at different stages of disease progression.
dc.language.isoen_US
dc.publisherPublic Library of Science
dash.licenseLAA
dc.titleAssociation of eGFR-Related Loci Identified by GWAS with Incident CKD and ESRD
dc.typeJournal Article
dc.description.versionVersion of Record
dc.relation.journalPLoS Genetics
dash.depositing.authorHofman, Albert::23effeffdfa95fe55437cc4d561aa487::600
dc.date.available2019-09-30T11:55:39Z
dash.workflow.comments1Science Serial ID 83963
dc.identifier.doi10.1371/journal.pgen.1002292
dash.source.volume7;9


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