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dc.contributor.authorFarwell, Wildon R.
dc.contributor.authorMichael Gaziano, J.
dc.contributor.authorNorkus, Edward P.
dc.contributor.authorSesso, Howard D.
dc.date.accessioned2019-09-30T11:55:48Z
dc.date.issued2008
dc.identifier.citationFarwell, Wildon R., J. Michael Gaziano, Edward P. Norkus, and Howard D. Sesso. 2008. “The Relationship between Total Plasma Carotenoids and Risk Factors for Chronic Disease among Middle-Aged and Older Men.” British Journal of Nutrition 100 (4): 883–89. https://doi.org/10.1017/s0007114508944111.
dc.identifier.issn0007-1145
dc.identifier.issn1475-2662
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:41426763*
dc.description.abstractIndividual plasma carotenoids have been associated with various chronic diseases but little is known about the relationship between total plasma carotenoids and risk-factors lot chronic diseases. In the Physicians' Health Study, we examined 492 men free of CVD and cancer for the relationship between total plasma carotenoids (the sum of alpha-carotene. beta-carotene, lycopene, zeaxanthin, lutein and beta-cryptoxanthin) and a wide variety of factors that predict chronic disease. Multivariate linear and logistic regression was performed to calculate parameter estimates (95% CI) and OR (95% CI) for total plasma carotenoids. In linear regression models, BMI, hypertension, alcohol intake and plasma levels of each lipid parameter and alpha-tocopherol significantly predicted levels of total plasma carotenoids. Upon adjustment for multiple chronic disease risk factors. the OR for levels of total plasma carotenoids greater than or equal to the median (>= 1.301 mu mol/l) was statistically significant for Current smoking. (OR 0.21; 95% CI 0.06; 0.77), weekly alcohol ingestion (OR 2.30; 95% CI 1.06; 4.99), daily alcohol ingestion (OR 2.46; 95 % CI 1.29; 467). each 100 mg/l increase in total cholesterol (OR 0.73; 95% CI 0.58; 0.91), HDL-cholesterol (OR 1.48; 95% CI 1.17; 1.89) and HDL-cholesterol (OR 1.58; 95% CI 1.26; 1.99), each 100 mg/ml increase in intercellular adhesion molecule-l (OR 0.70; 95% CI 0.53; 0.93) and each 10 mu mol/l increase in alpha-tocopherol (OR 1.33; 95% CI 1.12; 1.57), using logistic regression. Few lifestyle and clinical risk factors appear to be related to levels of total plasma carotenoid however, levels of biomarkers Such as plasma lipids and alpha-tocopheiol may he strongly related.
dc.language.isoen_US
dc.publisherCambridge University Press
dash.licenseLAA
dc.titleThe relationship between total plasma carotenoids and risk factors for chronic disease among middle-aged and older men
dc.typeJournal Article
dc.description.versionVersion of Record
dc.relation.journalThe British Journal of Nutrition
dash.depositing.authorSesso, Howard David::95dfa233726009bf496fb7d48c776a19::600
dc.date.available2019-09-30T11:55:48Z
dash.workflow.comments1Science Serial ID 103088
dc.identifier.doi10.1017/S0007114508944111
dash.source.volume100;4


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