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dc.contributor.authorKilpeläinen, Tuomas O.
dc.contributor.authorQi, Lu
dc.contributor.authorBrage, Soren
dc.contributor.authorSharp, Stephen J.
dc.contributor.authorSonestedt, Emily
dc.contributor.authorDemerath, Ellen
dc.contributor.authorAhmad, Tariq
dc.contributor.authorMora, Samia
dc.contributor.authorKaakinen, Marika
dc.contributor.authorSandholt, Camilla Helene
dc.contributor.authorHolzapfel, Christina
dc.contributor.authorAutenrieth, Christine S.
dc.contributor.authorHyppönen, Elina
dc.contributor.authorCauchi, Stéphane
dc.contributor.authorHe, Meian
dc.contributor.authorKutalik, Zoltan
dc.contributor.authorKumari, Meena
dc.contributor.authorStančáková, Alena
dc.contributor.authorMeidtner, Karina
dc.contributor.authorBalkau, Beverley
dc.contributor.authorTan, Jonathan T.
dc.contributor.authorMangino, Massimo
dc.contributor.authorTimpson, Nicholas J.
dc.contributor.authorSong, Yiqing
dc.contributor.authorZillikens, M. Carola
dc.contributor.authorJablonski, Kathleen A.
dc.contributor.authorGarcia, Melissa E.
dc.contributor.authorJohansson, Stefan
dc.contributor.authorBragg-Gresham, Jennifer L.
dc.contributor.authorWu, Ying
dc.contributor.authorvan Vliet-Ostaptchouk, Jana V.
dc.contributor.authorOnland-Moret, N. Charlotte
dc.contributor.authorZimmermann, Esther
dc.contributor.authorRivera, Natalia V.
dc.contributor.authorTanaka, Toshiko
dc.contributor.authorStringham, Heather M.
dc.contributor.authorSilbernagel, Günther
dc.contributor.authorKanoni, Stavroula
dc.contributor.authorFeitosa, Mary F.
dc.contributor.authorSnitker, Soren
dc.contributor.authorRuiz, Jonatan R.
dc.contributor.authorMetter, Jeffery
dc.contributor.authorLarrad, Maria Teresa Martinez
dc.contributor.authorAtalay, Mustafa
dc.contributor.authorHakanen, Maarit
dc.contributor.authorAmin, Najaf
dc.contributor.authorCavalcanti-Proença, Christine
dc.contributor.authorGrøntved, Anders
dc.contributor.authorHallmans, Göran
dc.contributor.authorJansson, John-Olov
dc.contributor.authorKuusisto, Johanna
dc.contributor.authorKähönen, Mika
dc.contributor.authorLutsey, Pamela L.
dc.contributor.authorNolan, John J.
dc.contributor.authorPalla, Luigi
dc.contributor.authorPedersen, Oluf
dc.contributor.authorPérusse, Louis
dc.contributor.authorRenström, Frida
dc.contributor.authorScott, Robert A.
dc.contributor.authorShungin, Dmitry
dc.contributor.authorSovio, Ulla
dc.contributor.authorTammelin, Tuija H.
dc.contributor.authorRönnemaa, Tapani
dc.contributor.authorLakka, Timo A.
dc.contributor.authorUusitupa, Matti
dc.contributor.authorRios, Manuel Serrano
dc.contributor.authorFerrucci, Luigi
dc.contributor.authorBouchard, Claude
dc.contributor.authorMeirhaeghe, Aline
dc.contributor.authorFu, Mao
dc.contributor.authorWalker, Mark
dc.contributor.authorBorecki, Ingrid B.
dc.contributor.authorDedoussis, George V.
dc.contributor.authorFritsche, Andreas
dc.contributor.authorOhlsson, Claes
dc.contributor.authorBoehnke, Michael
dc.contributor.authorBandinelli, Stefania
dc.contributor.authorvan Duijn, Cornelia M.
dc.contributor.authorEbrahim, Shah
dc.contributor.authorLawlor, Debbie A.
dc.contributor.authorGudnason, Vilmundur
dc.contributor.authorHarris, Tamara B.
dc.contributor.authorSørensen, Thorkild I. A.
dc.contributor.authorMohlke, Karen L.
dc.contributor.authorHofman, Albert
dc.contributor.authorUitterlinden, André G.
dc.contributor.authorTuomilehto, Jaakko
dc.contributor.authorLehtimäki, Terho
dc.contributor.authorRaitakari, Olli
dc.contributor.authorIsomaa, Bo
dc.contributor.authorNjølstad, Pål R.
dc.contributor.authorFlorez, Jose C.
dc.contributor.authorLiu, Simin
dc.contributor.authorNess, Andy
dc.contributor.authorSpector, Timothy D.
dc.contributor.authorTai, E. Shyong
dc.contributor.authorFroguel, Philippe
dc.contributor.authorBoeing, Heiner
dc.contributor.authorLaakso, Markku
dc.contributor.authorMarmot, Michael
dc.date.accessioned2019-09-30T11:56:06Z
dc.date.issued2011
dc.identifier.citationKilpeläinen, Tuomas O., Lu Qi, Soren Brage, Stephen J. Sharp, Emily Sonestedt, Ellen Demerath, Tariq Ahmad, et al. 2011. “Physical Activity Attenuates the Influence of FTO Variants on Obesity Risk: A Meta-Analysis of 218,166 Adults and 19,268 Children.” Edited by Cathryn Lewis. PLoS Medicine 8 (11): e1001116. https://doi.org/10.1371/journal.pmed.1001116.
dc.identifier.issn1549-1277
dc.identifier.issn1549-1676
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:41426784*
dc.description.abstractBackground: The FTO gene harbors the strongest known susceptibility locus for obesity. While many individual studies have suggested that physical activity (PA) may attenuate the effect of FTO on obesity risk, other studies have not been able to confirm this interaction. To confirm or refute unambiguously whether PA attenuates the association of FTO with obesity risk, we meta-analyzed data from 45 studies of adults (n=218,166) and nine studies of children and adolescents (n=19,268). Methods and Findings: All studies identified to have data on the FTO rs9939609 variant (or any proxy [r(2)>0.8]) and PA were invited to participate, regardless of ethnicity or age of the participants. PA was standardized by categorizing it into a dichotomous variable (physically inactive versus active) in each study. Overall, 25% of adults and 13% of children were categorized as inactive. Interaction analyses were performed within each study by including the FTOxPA interaction term in an additive model, adjusting for age and sex. Subsequently, random effects meta-analysis was used to pool the interaction terms. In adults, the minor (A-) allele of rs9939609 increased the odds of obesity by 1.23-fold/allele (95% CI 1.20-1.26), but PA attenuated this effect (p(interaction) = 0.001). More specifically, the minor allele of rs9939609 increased the odds of obesity less in the physically active group (odds ratio = 1.22/allele, 95% CI 1.19-1.25) than in the inactive group (odds ratio = 1.30/allele, 95% CI 1.24-1.36). No such interaction was found in children and adolescents. Conclusions: The association of the FTO risk allele with the odds of obesity is attenuated by 27% in physically active adults, highlighting the importance of PA in particular in those genetically predisposed to obesity.
dc.language.isoen_US
dc.publisherPublic Library of Science
dash.licenseLAA
dc.titlePhysical Activity Attenuates the Influence of FTO Variants on Obesity Risk: A Meta-Analysis of 218,166 Adults and 19,268 Children
dc.typeJournal Article
dc.description.versionVersion of Record
dc.relation.journalPLoS Medicine
dash.depositing.authorHofman, Albert::23effeffdfa95fe55437cc4d561aa487::600
dc.date.available2019-09-30T11:56:06Z
dash.workflow.comments1Science Serial ID 84001
dc.identifier.doi10.1371/journal.pmed.1001116
dash.source.volume8;11


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