Antibody-Independent, CD4+ T-Cell-Dependent Protection against Pneumococcal Colonization Elicited by Intranasal Immunization with Purified Pneumococcal Proteins
Thompson, Claudette M.
Hollingshead, Susan K.
Briles, David E.
Ades, Edwin W.
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CitationBasset, A., C. M. Thompson, S. K. Hollingshead, D. E. Briles, E. W. Ades, M. Lipsitch, and R. Malley. 2007. “Antibody-Independent, CD4+ T-Cell-Dependent Protection against Pneumococcal Colonization Elicited by Intranasal Immunization with Purified Pneumococcal Proteins.” Infection and Immunity 75 (11): 5460–64. https://doi.org/10.1128/iai.00773-07.
AbstractImmunity to pneumococcal colonization in mice by exposure to live or killed pneumococci has been shown to be antibody independent but dependent on CD4(+) T cells. Here we show that intranasal immunization with pneumococcal proteins (pneumococcal surface protein C, adhesin A, and a pneumolysoid) can elicit a similar mechanism of protection. Colonization could be significantly reduced in mice congenitally deficient in immunoglobulins after intranasal immunization with this mixture of proteins; conversely, the depletion of CD4(+) T cells in immunized wild-type mice at the time of challenge eliminated the protection afforded by immunization. Overall, our results show that intranasal immunization with a mixture of pneumococcal proteins protects against colonization in an antibody-independent, CD4(+) T-cell-dependent manner.
Citable link to this pagehttp://nrs.harvard.edu/urn-3:HUL.InstRepos:41426793
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