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dc.contributor.authorMurray, Christopher J. L.
dc.contributor.authorLopez, Alan D.
dc.contributor.authorBlack, Robert
dc.contributor.authorAhuja, Ramesh
dc.contributor.authorAli, Said Mohd
dc.contributor.authorBaqui, Abdullah
dc.contributor.authorDandona, Lalit
dc.contributor.authorDantzer, Emily
dc.contributor.authorDas, Vinita
dc.contributor.authorDhingra, Usha
dc.contributor.authorDutta, Arup
dc.contributor.authorFawzi, Wafaie
dc.contributor.authorFlaxman, Abraham D.
dc.contributor.authorGómez, Sara
dc.contributor.authorHernández, Bernardo
dc.contributor.authorJoshi, Rohina
dc.contributor.authorKalter, Henry
dc.contributor.authorKumar, Aarti
dc.contributor.authorKumar, Vishwajeet
dc.contributor.authorLozano, Rafael
dc.contributor.authorLucero, Marilla
dc.contributor.authorMehta, Saurabh
dc.contributor.authorNeal, Bruce
dc.contributor.authorOhno, Summer Lockett
dc.contributor.authorPrasad, Rajendra
dc.contributor.authorPraveen, Devarsetty
dc.contributor.authorPremji, Zul
dc.contributor.authorRamírez-Villalobos, Dolores
dc.contributor.authorRemolador, Hazel
dc.contributor.authorRiley, Ian
dc.contributor.authorRomero, Minerva
dc.contributor.authorSaid, Mwanaidi
dc.contributor.authorSanvictores, Diozele
dc.contributor.authorSazawal, Sunil
dc.contributor.authorTallo, Veronica
dc.date.accessioned2019-09-30T11:56:22Z
dc.date.issued2011
dc.identifier.citationMurray, Christopher JL, Alan D Lopez, Robert Black, Ramesh Ahuja, Said Mohd Ali, Abdullah Baqui, Lalit Dandona, et al. 2011. “Population Health Metrics Research Consortium Gold Standard Verbal Autopsy Validation Study: Design, Implementation, and Development of Analysis Datasets.” Population Health Metrics 9 (1). https://doi.org/10.1186/1478-7954-9-27.
dc.identifier.issn1478-7954
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:41426802*
dc.description.abstractBackground: Verbal autopsy methods are critically important for evaluating the leading causes of death in populations without adequate vital registration systems. With a myriad of analytical and data collection approaches, it is essential to create a high quality validation dataset from different populations to evaluate comparative method performance and make recommendations for future verbal autopsy implementation. This study was undertaken to compile a set of strictly defined gold standard deaths for which verbal autopsies were collected to validate the accuracy of different methods of verbal autopsy cause of death assignment. Methods: Data collection was implemented in six sites in four countries: Andhra Pradesh, India; Bohol, Philippines; Dar es Salaam, Tanzania; Mexico City, Mexico; Pemba Island, Tanzania; and Uttar Pradesh, India. The Population Health Metrics Research Consortium (PHMRC) developed stringent diagnostic criteria including laboratory, pathology, and medical imaging findings to identify gold standard deaths in health facilities as well as an enhanced verbal autopsy instrument based on World Health Organization (WHO) standards. A cause list was constructed based on the WHO Global Burden of Disease estimates of the leading causes of death, potential to identify unique signs and symptoms, and the likely existence of sufficient medical technology to ascertain gold standard cases. Blinded verbal autopsies were collected on all gold standard deaths. Results: Over 12,000 verbal autopsies on deaths with gold standard diagnoses were collected (7,836 adults, 2,075 children, 1,629 neonates, and 1,002 stillbirths). Difficulties in finding sufficient cases to meet gold standard criteria as well as problems with misclassification for certain causes meant that the target list of causes for analysis was reduced to 34 for adults, 21 for children, and 10 for neonates, excluding stillbirths. To ensure strict independence for the validation of methods and assessment of comparative performance, 500 test-train datasets were created from the universe of cases, covering a range of cause-specific compositions. Conclusions: This unique, robust validation dataset will allow scholars to evaluate the performance of different verbal autopsy analytic methods as well as instrument design. This dataset can be used to inform the implementation of verbal autopsies to more reliably ascertain cause of death in national health information systems.
dc.language.isoen_US
dc.publisherBMC
dash.licenseLAA
dc.titlePopulation Health Metrics Research Consortium gold standard verbal autopsy validation study: design, implementation, and development of analysis datasets
dc.typeJournal Article
dc.description.versionVersion of Record
dc.relation.journalPopulation Health Metrics
dash.depositing.authorFawzi, Wafaie W.::528a61b1c829b4a4452ed2e0290f7af9::600
dc.date.available2019-09-30T11:56:22Z
dash.workflow.comments1Science Serial ID 84019
dc.identifier.doi10.1186/1478-7954-9-27
dash.source.volume9


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