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dc.contributor.authorBasset, Alan
dc.contributor.authorTrzcinski, Krzysztof
dc.contributor.authorHermos, Christina
dc.contributor.authorO'BRIEN, Katherine
dc.contributor.authorReid, Raymond
dc.contributor.authorSantosham, Mathuram
dc.contributor.authorMcadam, Alexander
dc.contributor.authorLipsitch, Marc
dc.contributor.authorMalley, Richard
dc.date.accessioned2019-09-30T11:56:23Z
dc.date.issued2007
dc.identifier.citationBasset, A., K. Trzcinski, C. Hermos, K. L. O’Brien, R. Reid, M. Santosham, A. J. McAdam, M. Lipsitch, and R. Malley. 2007. “Association of the Pneumococcal Pilus with Certain Capsular Serotypes but Not with Increased Virulence.” Journal of Clinical Microbiology 45 (6): 1684–89. https://doi.org/10.1128/jcm.00265-07.
dc.identifier.issn0095-1137
dc.identifier.issn1070-633X
dc.identifier.issn1098-660X
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:41426804*
dc.description.abstractThe recent discovery of a mobile genetic element encoding a pilus-like structure in Streptococcus pneumoniae and the demonstration of a role for the pilus in virulence in mice have led to the proposal of the use of the pilus as a candidate pneumococcal vaccine. We examined the frequency of occurrence of the pneumococcal pilus, as determined by the presence of the rrgC gene, and analyzed its association with virulence, capsular serotypes, and multilocus sequence types in the American Indian pneumococcal collection and isolates of S. pneumoniae from blood cultures collected at Children's Hospital Boston. Overall, 21.4% of strains in the American Indian collection had the rrgC gene, but there was no difference between isolates obtained from the nasopharynx and those obtained from sterile sites (blood or cerebrospinal fluid). Vaccine-type strains were significantly more likely than non-vaccine-type strains to have this pilus gene (P < 0.001). Among isolates with identical multilocus sequence types, there was a high concordance (95%) between the multilocus sequence type and the presence or the absence of rrgC. Finally, in the era of the pneumococcal conjugate vaccine, the frequency of rrgC in isolates from Children's Hospital Boston has decreased significantly (42.8% before 2000 versus 21.3% after 2000; P = 0.019). Therefore, our data show that the pilus is present in a minority of strains and is associated with certain serotypes and that its frequency has been reduced by the conjugate pneumococcal vaccine.
dc.language.isoen_US
dc.publisherAmerican Society for Microbiology
dash.licenseLAA
dc.titleAssociation of the Pneumococcal Pilus with Certain Capsular Serotypes but Not with Increased Virulence
dc.typeJournal Article
dc.description.versionVersion of Record
dc.relation.journalJournal of Clinical Microbiology
dash.depositing.authorLipsitch, Marc::b95f55eb4c57b90cfbcee3171f1156b1::600
dc.date.available2019-09-30T11:56:23Z
dash.workflow.comments1Science Serial ID 45691
dc.identifier.doi10.1128/JCM.00265-07
dash.source.volume45;6
dash.source.page1684-1689


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