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dc.contributor.authorPan, An
dc.contributor.authorSchernhammer, Eva S.
dc.contributor.authorSun, Qi
dc.contributor.authorHu, Frank B.
dc.contributor.authorGroop, Leif
dc.date.accessioned2019-09-30T11:56:29Z
dc.date.issued2011
dc.identifier.citationPan, An, Eva S. Schernhammer, Qi Sun, and Frank B. Hu. 2011. “Rotating Night Shift Work and Risk of Type 2 Diabetes: Two Prospective Cohort Studies in Women.” Edited by Leif Groop. PLoS Medicine 8 (12): e1001141. https://doi.org/10.1371/journal.pmed.1001141.
dc.identifier.issn1549-1277
dc.identifier.issn1549-1676
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:41426812*
dc.description.abstractBackground: Rotating night shift work disrupts circadian rhythms and has been associated with obesity, metabolic syndrome, and glucose dysregulation. However, its association with type 2 diabetes remains unclear. Therefore, we aimed to evaluate this association in two cohorts of US women. Methods and Findings: We followed 69,269 women aged 42-67 in Nurses' Health Study I (NHS I, 1988-2008), and 107,915 women aged 25-42 in NHS II (1989-2007) without diabetes, cardiovascular disease, and cancer at baseline. Participants were asked how long they had worked rotating night shifts (defined as at least three nights/month in addition to days and evenings in that month) at baseline. This information was updated every 2-4 years in NHS II. Self-reported type 2 diabetes was confirmed by a validated supplementary questionnaire. We documented 6,165 (NHS I) and 3,961 (NHS II) incident type 2 diabetes cases during the 18-20 years of follow-up. In the Cox proportional models adjusted for diabetes risk factors, duration of shift work was monotonically associated with an increased risk of type 2 diabetes in both cohorts. Compared with women who reported no shift work, the pooled hazard ratios (95% confidence intervals) for participants with 1-2, 3-9, 10-19, and >= 20 years of shift work were 1.05 (1.00-1.11), 1.20 (1.14-1.26), 1.40 (1.30-1.51), and 1.58 (1.43-1.74, p-value for trend <0.001), respectively. Further adjustment for updated body mass index attenuated the association, and the pooled hazard ratios were 1.03 (0.98-1.08), 1.06 (1.01-1.11), 1.10 (1.02-1.18), and 1.24 (1.13-1.37, p-value for trend <0.001). Conclusions: Our results suggest that an extended period of rotating night shift work is associated with a modestly increased risk of type 2 diabetes in women, which appears to be partly mediated through body weight. Proper screening and intervention strategies in rotating night shift workers are needed for prevention of diabetes.
dc.language.isoen_US
dc.publisherPublic Library of Science
dash.licenseLAA
dc.titleRotating Night Shift Work and Risk of Type 2 Diabetes: Two Prospective Cohort Studies in Women
dc.typeJournal Article
dc.description.versionVersion of Record
dc.relation.journalPLoS Medicine
dash.depositing.authorHu, Frank B.::47e5696036c51681ef5e0e5da5872807::600
dc.date.available2019-09-30T11:56:29Z
dash.workflow.comments1Science Serial ID 83405
dc.identifier.doi10.1371/journal.pmed.1001141
dash.source.volume8;12


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