A Cost-Effectiveness Analysis of Folic Acid Fortification Policy in the United States
Willett, Walter C.::94559ea206eef8a8844fc5b80654fa5b::600
Kuntz, K. M.
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CitationBentley, Tanya GK, Milton C Weinstein, Walter C Willett, and Karen M Kuntz. 2008. “A Cost-Effectiveness Analysis of Folic Acid Fortification Policy in the United States.” Public Health Nutrition 12 (4): 455. https://doi.org/10.1017/s1368980008002565.
AbstractObjective: To quantity the health and economic Outcome, associated with changes in folic acid consumption following the fortification of enriched grain products in the USA. Design: Cost-effectiveness analysis. Setting: Annual burden of disease, quality-adjusted life years (QALY) and costs were projected for four steady-state strategies: no fortification, or fortifying with 140, 350 or 700 mu g folic acid per 100 g enriched grain. The analysis considered four health outcomes: neural tube defects (NTD), myocardial infarctions (MI), colon cancers and B(12) deficiency maskings.Subjects: The US adult Population subgroups defined by age, gender and race/ethnicity, with folate intake distributions from the National Health and Nutrition Examination Surveys (1988-1992 and 1999-2000), and reference Sources for disease incidence, utility and economic estimates. Results: he greatest benefits from fortification were predicted in MI prevention, with 16 862 and 88 172 cases averted per year in steady state for the 140 and 700 mu g fortification levels, respectively. These projections were between 6261 and 38805 for colon cancer and 182 and 1423 for NTD, while 15420 additional B(12) cases were predicted. Compared with no fortification, all post-fortification strategies provided QALY gains and cost savings for all subgroups, with predicted population benefits of 266649 QALY gained and $3-6 billion saved in the long run by changing the fortification level from 140 mu g/100 g enriched grain to 700 mu g/100 g. Conclusions: The present Study indicates that the health and economic gains of folic acid fortification far outweigh the losses for the US population, and that increasing the level of fortification deserves further consideration to maximise net gains.
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