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dc.contributor.authorWu, Hongyu
dc.contributor.authorDing, Eric L.
dc.contributor.authorToledo, Estefanía T.
dc.contributor.authorCampos, Hannia
dc.contributor.authorBaylin, Ana
dc.contributor.authorHu, Frank B.
dc.contributor.authorSun, Qi
dc.date.accessioned2019-09-30T11:56:55Z
dc.date.issued2013
dc.identifier.citationWu, Hongyu, Eric L. Ding, Estefanía T. Toledo, Hannia Campos, Ana Baylin, Frank B. Hu, and Qi Sun. 2013. “A Novel Fatty Acid Lipophilic Index and Risk of CHD in US Men: The Health Professionals Follow-Up Study.” British Journal of Nutrition 110 (3): 466–74. https://doi.org/10.1017/s0007114512005272.
dc.identifier.issn0954-4224
dc.identifier.issn1475-2700
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:41426842*
dc.description.abstractFew epidemiological studies have examined the association between an overall fatty acid (FA) profile and CHD risk. The aim of the present study was to examine a novel index that summarises individual FA levels based on FA affinity and fluidity in relation to CHD risk in men. In a prospective nested case-control study, FA in plasma and erythrocytes were measured in 459 CHD cases and 879 matched controls. Lipophilic index (LI) was computed by summing the products between FA levels and melting point of each FA to reflect the overall FA lipophilicity. Among controls, higher plasma LI was significantly correlated with adverse profiles of blood lipids, inflammatory markers and adiponectin. After multivariate adjustment for age, smoking, BMI and other CHD risk factors, plasma LI was significantly associated with an increased risk of CHD: the relative risk was 1.61 (95% CI 1.03, 2.53; P for trend=0.04) comparing extreme quintiles. This association was attenuated to 1.21 (95% CI 0.48, 3.09; P for trend=0.77) after adjusting for plasma levels of total trans-FA, long-chain n-3 FA and polyunsaturated:saturated fat ratio. Erythrocyte LI was not significantly associated with CHD risk. The present data indicate that a novel LI is associated with an adverse profile of cardiovascular risk markers and increased risk of CHD in men; its usefulness as a complement of individual FA in assessing disease risk needs to be elucidated in future studies.
dc.language.isoen_US
dc.publisherCambridge University Press
dash.licenseLAA
dc.titleA novel fatty acid lipophilic index and risk of CHD in US men: the Health Professionals Follow-Up Study
dc.typeJournal Article
dc.description.versionVersion of Record
dc.relation.journalNutrition Research Reviews
dash.depositing.authorHu, Frank B.::47e5696036c51681ef5e0e5da5872807::600
dc.date.available2019-09-30T11:56:55Z
dash.workflow.comments1Science Serial ID 72338
dc.identifier.doi10.1017/S0007114512005272
dash.source.volume110;3
dash.source.page466-474


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