Show simple item record

dc.contributor.authorWu, Jason H. Y.
dc.contributor.authorMicha, Renata
dc.contributor.authorImamura, Fumiaki
dc.contributor.authorPan, An
dc.contributor.authorBiggs, Mary L.
dc.contributor.authorAjaz, Owais
dc.contributor.authorDjousse, Luc
dc.contributor.authorHu, Frank B.
dc.contributor.authorMozaffarian, Dariush
dc.date.accessioned2019-09-30T11:56:56Z
dc.date.issued2012
dc.identifier.citationWu, Jason H. Y., Renata Micha, Fumiaki Imamura, An Pan, Mary L. Biggs, Owais Ajaz, Luc Djousse, Frank B. Hu, and Dariush Mozaffarian. 2012. “Omega-3 Fatty Acids and Incident Type 2 Diabetes: A Systematic Review and Meta-Analysis.” British Journal of Nutrition 107 (S2): S214–27. https://doi.org/10.1017/s0007114512001602.
dc.identifier.issn0954-4224
dc.identifier.issn1475-2700
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:41426843*
dc.description.abstractThe relationship between omega-3 polyunsaturated fatty acids (n-3 PUFA) from seafood sources (eicosapentaenoic acid, EPA; docosahexaenoic acid, DHA) or plant sources (alpha-linolenic acid, ALA) and risk of type 2 diabetes mellitus (DM) remains unclear. We systematically searched multiple literature databases through June 2011 to identify prospective studies examining relations of dietary n-3 PUFA, dietary fish and/or seafood, and circulating n-3 PUFA biomarkers with incidence of DM. Data were independently extracted in duplicate by 2 investigators, including multivariate-adjusted relative risk (RR) estimates and corresponding 95% CI. Generalized least-squares trend estimation was used to assess dose-response relationships, with pooled summary estimates calculated by both fixed-effect and random-effect models. From 288 identified abstracts, 16 studies met inclusion criteria, including 18 separate cohorts comprising 540 184 individuals and 25 670 cases of incident DM. Consumption of fish and/or seafood was not significantly associated with DM (n = 13 studies; RR per 100 g/d = 1.12, 95% CI = 0.94, 1.34); nor were consumption of EPA+DHA (n = 16 cohorts; RR per 250 mg/d = 1.04, 95% CI = 0.97, 1.10) nor circulating levels of EPA+DHA biomarkers (n = 5 cohorts; RR per 3% of total fatty acids = 0.94, 95% CI = 0.75, 1.17). Both dietary ALA (n = 7 studies; RR per 0.5 g/d = 0.93, 95% CI = 0.83, 1.04) and circulating ALA biomarker levels (n = 6 studies; RR per 0.1% of total fatty acid = 0.90, 95% CI = 0.80, 1.00, P=0.06) were associated with non-significant trend towards lower risk of DM. Substantial heterogeneity (I-2 similar to 80 %) was observed among studies of fish/seafood or EPA+DHA and DM; moderate heterogeneity (<55 %) was seen for dietary and biomarker ALA and DM. In unadjusted meta-regressions, study location (Asia vs. North America/Europe), mean BMI, and duration of follow-up each modified the association between fish/seafood and EPA+DHA consumption and DM risk (P-interaction <= 0.02 each). We had limited statistical power to determine the independent effect of these sources of heterogeneity due to their high collinearity. The overall pooled findings do not support either major harms or benefits of fish/seafood or EPA+DHA on development of DM, and suggest that ALA may be associated with modestly lower risk. Reasons for potential heterogeneity of effects, which could include true biologic heterogeneity, publication bias, or chance, deserve further investigation.
dc.language.isoen_US
dc.publisherCambridge University Press
dash.licenseLAA
dc.titleOmega-3 Fatty Acids and incident Type 2 Diabetes: A Systematic Review and Meta-Analysis
dc.typeJournal Article
dc.description.versionVersion of Record
dc.relation.journalNutrition Research Reviews
dash.depositing.authorHu, Frank B.::47e5696036c51681ef5e0e5da5872807::600
dc.date.available2019-09-30T11:56:56Z
dash.workflow.comments1Science Serial ID 74362
dc.identifier.doi10.1017/S0007114512001602
dash.source.volume107;0 2
dash.source.pageS214


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record