Effects of Body Fat on the Associations of High-Molecular-Weight Adiponectin, Leptin and Soluble Leptin Receptor with Metabolic Syndrome in Chinese
Hu, Frank B.
MetadataShow full item record
CitationYu, Danxia, Zhijie Yu, Qi Sun, Liang Sun, Huaixing Li, Jun Song, Ming Mi, et al. 2011. “Effects of Body Fat on the Associations of High-Molecular-Weight Adiponectin, Leptin and Soluble Leptin Receptor with Metabolic Syndrome in Chinese.” Edited by Cuilin Zhang. PLoS ONE 6 (2): e16818. https://doi.org/10.1371/journal.pone.0016818.
AbstractBackground: Little is known regarding the associations between high-molecular-weight (HMW-) adiponectin, leptin and soluble leptin receptor (sOB-R) and metabolic syndrome (MetS) in Chinese. Also few studies elucidate the effects of inflammation and body fat mass on the relations. Methods: Plasma HMW-adiponectin, leptin and sOB-R were measured among 1055 Chinese men and women (35 similar to 54 yrs). Whole body and trunk fat mass were determined by Dual-energy X-ray absorptiometry. MetS was defined by the updated NCEP/ATPIII criterion for Asian-Americans. Results: HMW-adiponectin was inversely associated with MetS in multivariate model including fat mass index (FMI), inflammatory markers, leptin and sOB-R (OR in the highest quartile =0.30, 95%CI 0.18 similar to 0.50, P<.0001). Plasma sOB-R was also inversely associated with MetS independent of body fatness and inflammatory markers, whereas the association was somewhat attenuated after adjusting HMW-adiponectin (OR for the highest quartile =0.78, 95%CI 0.47 similar to 1.32, P = 0.15). In contrast, leptin was associated with increased odds of MetS independent of inflammatory markers, HMW-adiponectin, and sOB-R (OR for the highest quartile =2.64, 95%CI 1.35 similar to 5.18, P = 0.006), although further adjustment for FMI abolished this association. Conclusions: HMW-adiponectin exhibited strong inverse associations with MetS independent of body composition, inflammation, leptin and sOB-R; while the associations of leptin and sOB-R were largely explained by fat mass or HMW-adiponectin, respectively.
Citable link to this pagehttp://nrs.harvard.edu/urn-3:HUL.InstRepos:41426845
- SPH Scholarly Articles 
Contact administrator regarding this item (to report mistakes or request changes)