dc.contributor.author | Kuo, Szu-Yu | |
dc.contributor.author | Castoreno, Adam | |
dc.contributor.author | Aldrich, Leslie | |
dc.contributor.author | Lassen, Kara | |
dc.contributor.author | Goel, Gautam | |
dc.contributor.author | Dančík, Vlado | |
dc.contributor.author | Kuballa, Petric | |
dc.contributor.author | Latorre, Isabel | |
dc.contributor.author | Conway, Kara | |
dc.contributor.author | Sarkar, Sovan | |
dc.contributor.author | Maetzel, Dorothea | |
dc.contributor.author | Jaenisch, Rudolf | |
dc.contributor.author | Clemons, Paul | |
dc.contributor.author | Schreiber, Stuart | |
dc.contributor.author | Shamji, Alykhan | |
dc.contributor.author | Xavier, Ramnik | |
dc.date.accessioned | 2019-10-03T14:38:28Z | |
dc.date.issued | 2015 | |
dc.identifier.citation | Kuo, Szu-Yu, Adam B. Castoreno, Leslie N. Aldrich, Kara G. Lassen, Gautam Goel, Vlado Dančík, Petric Kuballa, et al. 2015. “Small-Molecule Enhancers of Autophagy Modulate Cellular Disease Phenotypes Suggested by Human Genetics.” Proceedings of the National Academy of Sciences 112 (31): E4281–87. https://doi.org/10.1073/pnas.1512289112. | |
dc.identifier.issn | 0027-8424 | |
dc.identifier.issn | 0744-2831 | |
dc.identifier.issn | 1091-6490 | |
dc.identifier.uri | http://nrs.harvard.edu/urn-3:HUL.InstRepos:41461204 | * |
dc.description.abstract | Studies of human genetics and pathophysiology have implicated the regulation of autophagy in inflammation, neurodegeneration, infection, and autoimmunity. These findings have motivated the use of small-molecule probes to study how modulation of autophagy affects disease-associated phenotypes. Here, we describe the discovery of the small-molecule probe BRD5631 that is derived from diversity-oriented synthesis and enhances autophagy through an mTOR-independent pathway. We demonstrate that BRD5631 affects several cellular disease phenotypes previously linked to autophagy, including protein aggregation, cell survival, bacterial replication, and inflammatory cytokine production. BRD5631 can serve as a valuable tool for studying the role of autophagy in the context of cellular homeostasis and disease. | |
dc.language.iso | en_US | |
dc.publisher | National Academy of Sciences | |
dash.license | LAA | |
dc.title | Small-molecule enhancers of autophagy modulate cellular disease phenotypes suggested by human genetics | |
dc.type | Journal Article | |
dc.description.version | Version of Record | |
dc.relation.journal | Proceedings of the National Academy of Sciences of the United States of America | |
dash.depositing.author | Schreiber, Stuart L.::80f648d0514e642a8f97bb9b12b10db7::600 | |
dc.date.available | 2019-10-03T14:38:28Z | |
dash.workflow.comments | 1Science Serial ID 92273 | |
dc.identifier.doi | 10.1073/pnas.1512289112 | |
dash.source.volume | 112;31 | |
dash.source.page | E4281 | |