Mechanical control of tissue and organ development
View/ Open
Author
Mammoto, Tadanori
Ingber, Donald
Published Version
https://doi.org/10.1242/dev.024166Metadata
Show full item recordCitation
Mammoto, T., and D. E. Ingber. 2010. “Mechanical Control of Tissue and Organ Development.” Development 137 (9): 1407–20. https://doi.org/10.1242/dev.024166.Abstract
Many genes and molecules that drive tissue patterning during organogenesis and tissue regeneration have been discovered. Yet, we still lack a full understanding of how these chemical cues induce the formation of living tissues with their unique shapes and material properties. Here, we review work based on the convergence of physics, engineering and biology that suggests that mechanical forces generated by living cells are as crucial as genes and chemical signals for the control of embryological development, morphogenesis and tissue patterning.Terms of Use
This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAACitable link to this page
http://nrs.harvard.edu/urn-3:HUL.InstRepos:41461211
Collections
- FAS Scholarly Articles [17845]
Contact administrator regarding this item (to report mistakes or request changes)