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dc.contributor.authorZhang, Cheng-Zhong
dc.contributor.authorLeibowitz, Mitchell L.
dc.contributor.authorPellman, David
dc.date.accessioned2019-10-03T14:38:41Z
dc.date.issued2013
dc.identifier.citationZhang, C.-Z., M. L. Leibowitz, and D. Pellman. 2013. “Chromothripsis and beyond: Rapid Genome Evolution from Complex Chromosomal Rearrangements.” Genes & Development 27 (23): 2513–30. https://doi.org/10.1101/gad.229559.113.
dc.identifier.issn0890-9369
dc.identifier.issn1549-5477
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:41461218*
dc.description.abstractRecent genome sequencing studies have identified several classes of complex genomic rearrangements that appear to be derived from a single catastrophic event. These discoveries identify ways that genomes can be altered in single large jumps rather than by many incremental steps. Here we compare and contrast these phenomena and examine the evidence that they arise "all at once." We consider the impact of massive chromosomal change for the development of diseases such as cancer and for evolution more generally. Finally, we summarize current models for underlying mechanisms and discuss strategies for testing these models.
dc.language.isoen_US
dc.publisherCold Spring Harbor Laboratory Press
dash.licenseLAA
dc.titleChromothripsis and beyond: rapid genome evolution from complex chromosomal rearrangements
dc.typeJournal Article
dc.description.versionVersion of Record
dc.relation.journalGenes & Development
dash.depositing.authorPellman, David::f6b07cac8a1ce51be6494d29db5febbd::600
dc.date.available2019-10-03T14:38:41Z
dash.workflow.comments1Science Serial ID 41841
dc.identifier.doi10.1101/gad.229559.113
dash.source.volume27;23
dash.source.page2513


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